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Part Description

LP32459-7   von Willebrand factor cleaving protease inhibitor
von Willebrand factor (vWF) cleaving protease, or ADAMTS13, is a metalloprotease that cleaves vWF and thereby limits platelet aggregation and formation of microthrombi. vWF cleaving protease inhibitors can decrease the protease activity and/or more rapidly remove the enzyme from the circulation. Such inhibitors are one cause of thrombotic thrombocytopenic purpura (TTP), a disorder characterized by thrombocytopenia, anemia, fever, and neurologic and renal abnormalities. Idiopathic TTP is often due to anti-ADAMTS13 autoantibodies, while inherited TTP is an autosomal recessive disorder due to mutations in the ADAMTS13 gene that lead to impaired protease function. Work-up of patients with TTP can include vWF cleaving protease activity and, if that activity is low, inhibitor screen followed by quantification. PMID: 18756543 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
von Willebrand factor cleaving protease inhibitor:PrThr:Pt:PPP:Ord:
Long Common Name
von Willebrand factor (vWf) cleaving protease inhibitor [Presence] in Platelet poor plasma
Short Name
vWF Cp Inhib PPP Ql
Display Name
vWf cleaving protease inhibitor Ql (PPP)
Consumer Name Alpha Get Info
vWf cleaving protease inhibitor, Blood

Part Model Get Info

  • Component
    von Willebrand factor cleaving protease inhibitor
    LP32459-7
    • Analyte
      von Willebrand factor cleaving protease inhibitor
      LP32459-7
      • Component Numerator
        von Willebrand factor cleaving protease inhibitor
        LP32459-7
        • Component Numerator Core
          von Willebrand factor cleaving protease inhibitor
          LP32459-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    PPP
    LP7494-0
    • System Core
      PPP
      LP7494-0
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    NULL
     

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 2.10
Last Updated
Version 2.73 (MIN)
Change Reason
Changed Property from "ACnc" to "Pr" (Presence) to clarify that results (e.g. pos/neg, present/absent) are based on the presence of the inhibitor.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
15570

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)von Willebrandův faktor (vWf) štěpící proteáza inhibitor:Přítomnost nebo práh:Časový bod:Plazma chudá na trombocyty:Ordinální:
el-GRGreek (Greece)αναστολέας πρωτεάσης διάσπασης παράγοντα Von Willebrand:PrThr:Pt:PPP:Ord:
Synonyms: COAG Ord PPP PrThr Pt αναστολέας πρωτεάσης διάσπασης παράγοντα Von Willebrand παράγοντας Von Willebrand πρωτεάση διάσπασης παράγοντα Von Willebrand
es-ARSpanish (Argentina)inhibidor de la proteasa desdobladora del factor de von Willebrand:concentración arbitraria:punto en el tiempo:plasma desplaquetado:ordinal:
es-ESSpanish (Spain)Inhibidor de la proteasa divisora del Factor de von Villebrand:PrThr:Punto temporal:Plasma pobre en plaquetas:Ord:
es-MXSpanish (Mexico)Inhibidor de la proteasa que escinde el factor von Willebrand:Presencia o umbral:Punto temporal:Plasma pobre en plaquetas:Ordinal:
fr-CAFrench (Canada)Inhibiteur de la protéase clivage du Facteur von Willebrand:Présence-Seuil:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
fr-FRFrench (France)Facteur Willebrand inhibiteur de la protéase:Présence/Seuil:Ponctuel:Plasma pauvre en plaquettes:Qualitatif:
fr-BEFrench (Belgium)Inhibiteur de la protéase de coupage Facteur von Willebrand:PrThr:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
Synonyms: Fvw
it-ITItalian (Italy)von Willebrand, inibitore proteasi di taglio fattore:PrThr:Pt:PPP:Ord:
Synonyms: Fattore di von Willebrand (vWf) Inibitore di proteasi di taglio del fattore di von Plasma povero di piastrine Presenza o Soglia Proteasi di taglio del fattore di von Willebrand Punto nel tempo (episodio) Studio di coagulazione
ko-KRKorean (Korea, Republic Of)폰 빌레브란트 인자 절단 단백분해효소 억제인자:임의농도:검사시점:혈소판제거혈장:순위척도:
nl-NLDutch (Netherlands)von Willebrand-factor cleaving protease inhibitor:aanwezigheid:moment:plaatjesarm plasma:ordinaal:
Synonyms: coagulatiemethode
pl-PLPolish (Poland)Inhibitor proteazy rozkładającej czynnik von Willebranda:granica wykrywalności:punkt w czasie:osocze ubogopłytkowe:uporządkowany:
Synonyms: ADAMTS13 Czynnik von Willebranda (vWf) Inhibitor ADAMTS13 PPP
pt-BRPortuguese (Brazil)fator de von Willebrand clivagem da protease inibidor:ACnc:Pt:PPPQ:Ord:
Synonyms: ; vWF Cp Inhib; ADAMTS13 inhibitor; vWCP; VWF-cp; VWFCP; vWf; Arbitrary concentration; Point in time; Random; Platelet poor plasma; Plas; Ql; Ordinal; QL; Qualitative; Qual; Screen; Vonwillebrand; Von will; PR; Inhibit; Fac; Fact; COAGULATION
ru-RURussian (Russian Federation)von Willebrand (vWf) расщепляющая протеаза ингибитор:PrThr:ТчкВрм:ОПП:Пор:
Synonyms: Обеднённая пластинками плазма;Бедная тромбоцитами плазма Порядковый Точка во времени;Момент
tr-TRTurkish (Turkey)von Willebrand faktörü parçalıyıcı proteaz inhibitörü:MevcEşik:Zmlı:TFkP:Srl:
Synonyms: Mevcut
uk-UAUkrainian (Ukraine)інгібітор протеази, що розщеплює Фактор фон Віллебранда:Наявність або Поріг:МоментЧасу:Бідна тромбоцитами плазма:Порядково:
Synonyms: ADAMTS13; ADAMTS-13; ADAMTS13 inhibitor; COAGULATION; Fac; Fact; Hematology; Heme; Inhib; Inhibit; Ordinal; Plas; Platelet poor plasma; Point in time; PR; QL; Qual; Qualitative; Random; Screen; TTP; Von will; Vonwillebrand; vWCP; vWf; vWF Cp; vWF Cp Inhib; VWFCP; VWF-cp
zh-CNChinese (China)von Willebrand 因子裂解蛋白酶抑制剂:存在情况或阈值:时间点:贫血小板血浆:序数型:
Synonyms: von Willebrand von Willebrand 因子（von Willebrand Factor，vWf）;vWf;vWf 因子;血管性假血友病因子;血管性血友病因子 von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）裂解蛋白酶;ADAMTS13;von Willebrand 因子裂解蛋白酶（von Willebrand Factor Cleaving Protease，VWF-cp）;von Willebrand 因子裂解酶;vWCP;vWf 因子裂解蛋白酶;vWf 因子裂解酶;vWf 裂解酶;VWFCP;VWF-cp;血管性血友病因子裂解蛋白酶;血管性血友病因子裂解酶 von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）裂解蛋白酶抑制剂;ADAMTS13 抑制剂;von Willebrand 因子裂解酶抑制剂;vWf 因子裂解蛋白酶抑制剂;vWf 因子裂解酶抑制剂;vWf 裂解蛋白酶抑制剂;vWf 裂解酶抑制剂;血管性血友病因子裂解蛋白酶抑制剂;血管性血友病因子裂解酶抑制剂 乏血小板血浆;Platelet poor plasma;PPP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 冯·威勒布兰德 冯威勒布兰德 冯威勒布兰德氏 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抑制因子 抑制物 抑制物质 时刻;随机;随意;瞬间 朊酶 系数 蛋白质酵素

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