3521-2

cycloSPORINE [Mass/volume] in Serum

Discouraged

Status Information

Status: DISCOURAGED
Comment: Whole blood specimens should be used to follow cyclosporine levels rather than serum.

Term Description

Whole blood is the specimen of choice for Cyclosporin, but is sometimes performed on serum or plasma and we have included terms with these systems to allow users the choice.

Part Description

LP16098-3 cycloSPORINE
Cyclosporine (Brand names Neoral, Restasis, Sandimmune, Gengraf) is a cyclic undecapeptide of fungal origin and a potent calcineurin inhibitor immunosuppressive agent. The introduction of cyclosporine in human organ transplantation substantially improved patient and graft survival in patients receiving heart, kidney, liver, pancreas, lung or bone marrow transplants. Cyclosporine was the first drug to specifically and reversibly inhibit the activation and proliferation of lymphocytes. The main mechanism through which cyclosporine exerts its immunosuppressive effect is the inhibition of T cell activation and proliferation. Monitoring and concentration-controlled dosing is required to maintain patient drug levels within a narrow therapeutic window; low levels could cause transplant rejection and high levels may cause nephrotoxicity. PMID: 19545653 Source: Regenstrief LOINC, PMID: 19545653

LOINC Names Get Info

Fully-Specified Name: cycloSPORINE:MCnc:Pt:Ser:Qn:
Long Common Name: cycloSPORINE [Mass/volume] in Serum
Short Name: cycloSPORINE Ser-mCnc
Display Name: cycloSPORINE (S) [Mass/Vol]
Consumer Name Alpha Get Info: cycloSPORINE, Blood

Part Model Get Info

Component
cycloSPORINE
LP16098-3
- Analyte
  cycloSPORINE
  LP16098-3
  - Component Numerator
    cycloSPORINE
    LP16098-3
    - Component Numerator Core
      cycloSPORINE
      LP16098-3
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 1.0
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 3109

Member of these Groups Get Info

LOINC Group	Group Name
LG3077-7	Cyclosporine\|MCnc\|Pt\|ANYBldSerPl
LG43294-4	Cyclosporine\|Pt\|Ser

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Cyklosporin:Hmotnostní koncentrace:Časový bod:Sérum:Kvantitativní:
el-GR	Greek (Greece)	Κυκλοσπορίνη:MCnc:Pt:Ορός:Qn: Synonyms: DRUG/TOX MCnc Pt Qn Κυκλοσπορίνη Ορός
es-AR	Spanish (Argentina)	ciclosporina:concentración de masa:punto en el tiempo:suero:cuantitativo:
es-ES	Spanish (Spain)	Ciclosporina:Concentración de masa:Punto temporal:Suero:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	cicloesporino:Concentración de masa:Punto temporal:Suero:Cuantitativo:
et-EE	Estonian (Estonia)	Tsüklosporiin:MCnc:Pt:S:Qn: Synonyms: Juhuslik Kvantitatiivne Seerum
fr-CA	French (Canada)	Cyclosporine:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:
fr-BE	French (Belgium)	Cyclosporine:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:
fr-FR	French (France)	Ciclosporine:Masse/Volume:Ponctuel:Sérum:Numérique:
it-IT	Italian (Italy)	Ciclosporina:MCnc:Pt:Siero:Qn: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Punto nel tempo (episodio) Siero
ko-KR	Korean (Korea, Republic Of)	시클로스포린:질량농도:검사시점:혈청:정량:
nl-NL	Dutch (Netherlands)	ciclosporine:massa/volume:moment:serum:kwantitatief:
pl-PL	Polish (Poland)	Cyklosporyna:stężenie masowe:punkt w czasie:surowica:ilościowy:
pt-BR	Portuguese (Brazil)	Ciclosporina:MCnc:Pt:Soro:Qn: Synonyms: ; Cyclosporin; Cyclosporins; CsA; Ciclosporin; Ciclosporine; Neoral; SangCya; Cyclosporin a; Sandimmune; Mass concentration; Level; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU	Russian (Russian Federation)	Циклоспорин:МассКонц:ТчкВрм:Сыв:Колич: Synonyms: Количественный Массовая концентрация Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Siklosporin:KütlKons:Zmlı:Ser:Kant:
zh-CN	Chinese (China)	环孢菌素:质量浓度:时间点:血清:定量型: Synonyms: 可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间毒品毒品类水平;浓度;质量浓度(单位体积) 环孢霉素A; 山地明环孢灵; 环孢多肽A; 环孢素; 赛斯平; 环孢菌素; 环孢菌素A; 环孢素A;山地明;环孢多肽;环孢抑制剂;环孢灵;环孢霉素;环孢霉素A;环孢素;Cyclosporine;Cyclosporin; Restasis; Cyclosporine A; cyclosporin A; Antibiotic S 7481F1; 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonameth 药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类

Example Units

Unit	Source
ng/mL	Example UCUM Units
ng/mL	REGENSTRIEF

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=3521-2

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.