39021-1
Abnormal Prion Protein [Presence] in Tissue by Immunoassay
Active
Part Description
LP35078-2 Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms.
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Source: Wikipedia, Transmissible spongiform encephalopathy
Fully-Specified Name
- Component
- Prion protein.abnormal
- Property
- PrThr
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- IA
Additional Names
- Short Name
- Abn Prion Prot Tiss Ql IA
- Display Name
- Abnormal Prion Protein IA Ql (Tiss)
- Consumer Name Alpha Get Info
- Abnormal prion protein, Tissue
Example Answer List: LL2038-9
Source: Quest Diagnostics Inc.| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 | ||
| IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) | LA11884-6 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.15
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Prionenprotein.abnorm: |
| es-ES | Spanish (Spain) | Proteína priónica anormal: |
| es-MX | Spanish (Mexico) | Proteína priónica anormal: |
| fr-CA | French (Canada) | Protéines prion.anormales: |
| fr-FR | French (France) | Protéine prion anormale: |
| fr-BE | French (Belgium) | Protéines prion.anormales: |
| it-IT | Italian (Italy) | Proteina prionica.anormale: Synonyms: Immunoassay Microbiologia Presenza o Soglia Proteina Prionica Anormale Punto nel tempo (episodio) Tessuto & |
| ko-KR | Korean (Korea, Republic Of) | 프리온 단백.이상: |
| nl-NL | Dutch (Netherlands) | prioneiwit.abnormaal: Synonyms: IA |
| pt-BR | Portuguese (Brazil) | Proteína prion.anormal: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Прионный протеин.аномальный: Synonyms: Белок Порядковый Прионный белок.аномальный Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | Prion protein.anormal: Synonyms: İmmünölçüm, immünoassay Mevcut |
| zh-CN | Chinese (China) | 朊病毒蛋白.异常: Synonyms: BSE; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=39021-1
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