Version 2.78

Part Descriptions

LP21132-3   Chikungunya virus
A species of ALPHAVIRUS causing an acute dengue-like fever. Source: National Library of Medicine, MeSH 2006

LP21132-3   Chikungunya virus
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. PMID: 20111039
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage. Source: Regenstrief LOINC

LP6304-2   HAI
The hemagglutination-inhibition assay (HAI) can be used to identify subtypes of hemagglutinin producing viruses, such as Influenza. HAI can also be used to identify the subtype-specificity of antibodies against the virus. Normally, Influenza's hemagglutinin glycoprotein binds to receptors on the surface of red blood cells, causing them to agglutinate. If antibodies specific to the virus are present in the patient sample, they will bind to the virus, which prevents the virus from binding to the red blood cells and therefore prevents agglutination. To determine which subtype of virus is present, a viral isolate is tested against a series of antibodies with known subtype specificities. Whichever antibody inhibits red cell agglutination identifies the viral subtype. Similarly, antibody specificity is identified by testing the patient sample against known virus subtypes. PMID: 24899416 Source: Regenstrief LOINC

Fully-Specified Name

Component
Chikungunya virus Ab
Property
Titr
Time
Pt
System
Ser
Scale
SemiQn
Method
HAI

Additional Names

Short Name
CHIKV Ab Titr Ser HAI
Display Name
CHIKV Ab HAI (S) [Titer]
Consumer Name Alpha Get Info
Chikungunya virus antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.75
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG51028-5 Chikungunya virus

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Chikungunya-Virus Ak:Titer:Zeitpunkt:Serum:Semiquantitativ:Hämagglutinationshemmtest
es-ES Spanish (Spain) Virus Chikungunya Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:Inhibición de la Hemaglutinación
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Virus de Chikungunya Ab:Título:Punto temporal:Suero:Cuantitativo:Inhibición de la hemaglutinación
fr-FR French (France) Chikungunya virus Ac:Titre:Ponctuel:Sérum:Semi-Quantitatif:Hémagglutination indirecte
fr-CA French (Canada) Virus Chikungunya, Ac:Titre:Temps ponctuel:Sérum:SemiQn:Inhibition de l'hémagglutination
it-IT Italian (Italy) Chikungunya virus Ab:Titr:Pt:Siero:SemiQn:HAI
Synonyms: anticorpo CHIK Inibizione dell''emoagglutinazione Microbiologia Punto nel tempo (episodio) Siero Titolo
ko-KR Korean (Korea, Republic Of) 치쿤구냐 바이러스 항체:역가:검사시점:혈청:정량:적혈구응집 억제
nl-NL Dutch (Netherlands) Chikungunya-virus As:titer:moment:serum:semikwantitatief:hemagglutinatieremming
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Wirus Chikungunya Ab:miano:punkt w czasie:surowica:półilościowy:hamowanie hemaglutynacji
Synonyms: Przeciwciała do wirusa Chikungunya Wirus Chikungunya
pt-BR Portuguese (Brazil) Chikungunya vírus Ac:Título:Pt:Soro:Qn:Inibição da hemaglutinação
Synonyms: ; CHIKV; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Hemagglutination inhibition; HI; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Microbiology
zh-CN Chinese (China) 基孔肯亚病毒 抗体:滴定度:时间点:血清:半定量型:红细胞凝集抑制试验法
Synonyms: Ab;自身抗体 CHIKV Ab CHIKV 抗体 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 基孔肯亚病毒 Ab 基孔肯雅病毒 Ab 基孔肯雅病毒抗体 奇昆古尼亚病毒;基孔肯雅病毒;CHIKV 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 红细胞凝集抑制试验

Example Units

Unit Source
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=40505-0