Version 2.77

Part Description

LP35594-8   Thyroid transcription factor 1
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.

Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and diencephalon. It is also known as thyroid specific enhancer binding protein. It is used in anatomic pathology as a marker to determine if a tumor arises from the lung or thyroid.

TTF-1 positive cells are found in the lung as type II pneumocytes and Clara cells. In the thyroid, follicular and parafollicular cells are also positive for TTF-1.

For lung cancers, adenocarcinomas are usually positive, while squamous cell carcinomas and large cell carcinomas are rarely positive. Small cell carcinomas (of any primary site) are usually positive. TTF1 is more than merely a clinical marker of lung adenocarcinoma. It plays an active role in sustaining lung cancer cells in view of the experimental observation that it is mutated in lung cancer. TTF-1 staining is often positive in pulmonary adenocarcinomas, large cell carcinomas, small-cell lung carcinomas, neuroendocrine tumors other than small-cell lung carcinomas and extrapulmonary small-cell carcinomas. It is also positive in thyroid cancers and is used for monitoring for metastasis and recurrence. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Thyroid transcription factor 1 Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
TTF1 Ag Tiss Ql ImStn
Display Name
Thyroid transcription factor 1 Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
Thyroid transcription factor 1 antigen, Tissue

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
11840

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Factor 1 de transcripción tiroideo Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Factor de transcripción tiroideo 1 Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
fr-CA French (Canada) Thyroïdotranscription facteur 1 , Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FR French (France) TTF-1 antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
fr-BE French (Belgium) Thyroïd transcription facteur 1 Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
Synonyms: Antigène Coloration. Méthode mmunologique
it-IT Italian (Italy) Tiroide, fattore 1 di trascrizione , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Fattore 1 di trascrizione tiroideo Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) thyroïd transcriptiefactor 1 Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
Synonyms: antigeen thyroid transcriptiefactor 1
pt-BR Portuguese (Brazil) Fator de transcrição da tireóide 1 Ag:ACnc:Pt:Tecido:Ord:Imunocoloração
Synonyms: ; TTF1; TTF-1; Arbitrary concentration; Point in time; Random; Tissue; Ql; Ordinal; QL; Qualitative; Qual; Screen; ImStn; Immunostain; Immunohistochemical stain; IHC; Antigen; Antigens; Imun; Imune; Imm; Fac; Fact; I; PATHOLOGY
ru-RU Russian (Russian Federation) Тиреоидный фактор транскрипции 1 Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) Tiroid transkripsiyon faktörü 1 Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama
Synonyms: Antijen Mevcut
zh-CN Chinese (China) 甲状腺转录因子 1 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: Ⅰ Ag I TTF1 Ag TTF-1 Ag TTF1 抗原 TTF-1 抗原 TTF1;TTF-1;Thyroid transcription factor 1 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 甲状腺特异性 甲状腺的 甲状腺转录因子 1 Ag 甲状腺转录因子-1 Ag 甲状腺转录因子-1 抗原 着色 着色方法 着色法 系数

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=40564-7