LOINC
Version 2.67

42358-2HLA-B*57:01 [Presence] in Unspecified specimenActive

Part Descriptions

LP36049-2   HLA-B*57:01
Part of HLA-B57 allele family that is associated with Abacavir hypersensitivity reaction (AHSR) Source: Regenstrief Institute

LP36049-2   HLA-B*57:01
The human leukocyte antigen B (HLA-B) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. The antiretroviral medication abacavir specifically interacts with HLA-B*57:01 and alters the repertoire of self-peptides that are presented to T lymphocytes, which activates an immune reaction known as a hypersensitivity reaction. [PMID: 24561393] See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Fully-Specified Name

Component
HLA-B*57:01
Property
PrThr
Time
Pt
System
XXX
Scale
Ord
Method

Additional Names

Short Name
HLA-B*57:01 XXX Ql
Display Name
HLA-B*57:01 Ql (Unsp spec)

Basic Attributes

Class
HLA
Type
Laboratory
First Released
Version 2.16
Last Updated
Version 2.56
Change Reason
Changed answer list from "Normative" to "Example" to fit the current LOINC model.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
HLA-B*57:01:存在情况或阈值:时间点:XXX:序数型:
nl-NLDutch (NETHERLANDS)
HLA-B*5701:aanwezigheid:moment:XXX:ordinaal:
et-EEEstonian (ESTONIA)
HLA-B5701:PrThr:Pt:XXX:Ord:
fr-BEFrench (BELGIUM)
HLA-B5701:PrThr:Temps ponctuel:XXX:Ordinal:
fr-CAFrench (CANADA)
HLA-B*57:01:Présence-Seuil:Temps ponctuel:XXX:Ordinal:
fr-FRFrench (FRANCE)
HLA-B*57:01:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:
it-ITItalian (ITALY)
HLA-B*57:01:PrThr:Pt:XXX:Ord:
ko-KRKorean (KOREA, REPUBLIC OF)
사람 조직적합 복합체 유도 항원-B5701:임의농도:검사시점:XXX:순위척도:
pt-BRPortuguese (BRAZIL)
HLA-B5701:ACnc:Pt:XXX:Ord:
ru-RURussian (RUSSIAN FEDERATION)
HLA-B*5701:PrThr:ТчкВрм:XXX:Пор:
es-ESSpanish (SPAIN)
HLA-B*57:01:PrThr:Punto temporal:XXX:Ord:
tr-TRTurkish (TURKEY)
HLA-B*5701:MevcEşik:Zmlı:XXX:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=42358-2