Version 2.77

Part Description

LP36220-9   Insulin-like growth factor-I receptor
The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor. Mice carrying only one functional copy of igf1r are normal, but exhibit a ~15% decrease in body mass.

The IGF-1R is implicated in several cancers,[4][5] including both breast and prostate cancer. In some instances its anti-apoptotic properties allow cancerous cells to resist the cytotoxic properties of chemotheraputic drugs or radiotherapy. In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor. This process is referred to as crosstalk between EGFR and IGF-1R. It is further implicated in breast cancer by increasing the metastatic potential of the original tumour by inferring the ability to promote vascularisation.

Increased levels of the IGF-IR are expressed in the majority of primary and metastatic prostate cancer patient tumors.Evidence suggests that IGF-IR signaling is required for survival and growth when prostate cancer cells progress to androgen independence. In addition, when immortalized prostate cancer cells mimicking advanced disease are treated with the IGF-1R ligand, IGF-1, the cells become more motile. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Insulin-like growth factor-I receptor Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
IGF-IR Ag Tiss Ql ImStn
Display Name
Insulin-like growth factor-I receptor Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
Insulin-like growth factor-I receptor antigen, Tissue

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.16
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Receptor del factor I de crecimiento tipo insulina Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Receptor Ag del factor de crecimiento similar a la insulina I:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
et-EE Estonian (Estonia) Insuliinisarnane kasvufaktori 1 retseptor antigeen:PrThr:Pt:Tis:Ord:Immuunvärv
Synonyms: Järgarvuline Juhuslik Kude
fr-CA French (Canada) Récepteur à facteur de croissance insulinomimétique-I , Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FR French (France) IGF-1 récepteur antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
fr-BE French (Belgium) Récepteur . facteur de croissance insulinomimétique-I Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
Synonyms: Antigène Coloration. Méthode mmunologique IGF IGF-I. Récepteur
it-IT Italian (Italy) Fattore di crescita insulino-simile I, recettore , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Recettore del fattore di crescita insulino-simile Tessuto & Strisci
nl-NL Dutch (Netherlands) insulin-like growth factor-I-receptor Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
Synonyms: antigeen
pt-BR Portuguese (Brazil) Receptor de Fator-I de crescimento Insulin-like(IGF-1) Ag:ACnc:Pt:Tecido:Ord:Imunocoloração
Synonyms: ; IGF-IR; IGFIR; IGF1R; IGF-1R; IGF-I; IGF-1; Somatomedin C; IGF; Insul; Humulin; HUM; IH7; Lente; NPH; Semilente; Ultralente; Sliding; Arbitrary concentration; Point in time; Random; Tissue; Ql; Ordinal; QL; Qualitative; Qual; Screen; ImStn; Immunostain; Immunohistochemical stain; IHC; Antigen; Antigens; Imun; Imune; Imm; Recep; Recp; Rec; Receptors; Recept; Recptr; FI; Factor 1; Fac; Fact; PATHOLOGY
ru-RU Russian (Russian Federation) Инсулиноподобный ростовой фактор-I рецептор Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) İnsülin benzeri büyüme faktörü-I reseptörü Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama
Synonyms: Antijen Mevcut
zh-CN Chinese (China) 胰岛素样生长因子-I受体 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: "sliding scale" 胰岛素剂量调整法;HUM;Humulin;IH7;Insul;Lente;NPH;Semilente;Sliding;Ultralente;中性鱼精蛋白胰岛素(NPH 胰岛素);人胰岛素;优泌林;优泌林(Humulin,人工胰岛素,人胰岛素,重组人胰岛素);半慢胰岛素;半慢胰岛素(Semilente);慢效胰岛素;慢效胰岛素(Lente);慢胰岛素;特慢胰岛素;特慢胰岛素(Ultralente);胰岛素制剂;蛇麻素(Humulin);超慢胰岛素;长效胰岛素 Ag FI I 型 IGF;ILGF;胰岛素样生长因子(Insulin-like growth factors,ILGF) IGF1R;IGF-1R;IGFIR;IGF-IR;胰岛素样生长因子(Insulin-like growth factor-I receptor,IGF-IR) IGF-I;Somatomedin c;促生长因子 c;生长因子 c;生长调节素 c;胰岛素样生长因子 I;胰岛素样生长因子Ⅰ;胰岛素样生长因子-Ⅰ;胰岛素样生长因子-I(Insulin-like Growth Factor-I,IGF-I) ILGF-I Ag 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 因子 1 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 系数 胰岛素样生长因子 I Ag 胰岛素样生长因子ⅠAg 胰岛素样生长因子-ⅠAg 胰岛素样生长因子Ⅰ抗原 胰岛素样生长因子-Ⅰ抗原 胰岛素样生长因子-I Ag 胰岛素样生长因子-I 抗原

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=42788-0