Version 2.78

Part Descriptions

LP16737-6   Rabies virus
Rabies virus (RV), is an enveloped, single-stranded, negative sense RNA virus and a member of the Rhabdoviridae family. It is transmitted when an animal infected with RV bites an individual or the saliva from an infected animal comes into contact with an open wound. Once RV penetrates the muscle or connective tissue it begins to replicate and then infiltrates the peripheral nerves through the neuromuscular junction. From there, RV spreads to the central nervous system (CNS) in the endoneurium of the Schwann cells. If bitten by an animal that may have RV infection, rabies immune globulin and rabies vaccine should be administered. Otherwise, there is no treatment for infection by RV other than supportive care, and acute infection of the CNS is almost always fatal. In countries where preventative care is not practiced, RV is still widespread. In Asia, 30,000 people die annually from RV infection. Diagnosis of RV is done on two tissue specimens from the brain that are analyzed by direct fluorescent antibody (DFA), mouse inoculation, tissue culture and polymerase chain reaction.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307483/] Source: Regenstrief LOINC

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

Fully-Specified Name

Component
Rabies virus Ab.Neut
Property
Titr
Time
Pt
System
Ser
Scale
SemiQn
Method
Neut

Additional Names

Long Common Name
Rabies virus neutralizing antibody [Titer] in Serum by Neutralization test
Short Name
RABV NAb Titr Ser Nt
Display Name
Rabies virus neut ab Neut test (S) [Titer]
Consumer Name Alpha Get Info
Rabies virus neutralizing antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.75
Change Reason
Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG32755-7 Rabies virus

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Rabiesvirus AK NT
de-DE German (Germany) Rabies-Virus Ak.neutralisierend:Titer:Zeitpunkt:Serum:Semiquantitativ:Neutralisationstest
Synonyms: Rabies lyssavirus
es-MX Spanish (Mexico) Virus de la rabia Ab:Título:Punto temporal:Suero:Cuantitativo:Prueba de neutralización
es-ES Spanish (Spain) Virus de la Rabia Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:Prueba de neutralización
Synonyms: Semicuantitativo
fr-CA French (Canada) Virus de la rage Ac.neut:Titre:Temps ponctuel:Sérum:SemiQn:Test de neutralisation
fr-FR French (France) Rage virus Ac neutralisant:Titre:Ponctuel:Sérum:Semi-Quantitatif:Neutralisation
it-IT Italian (Italy) Rabbia, virus Ab.Neut:Titr:Pt:Siero:SemiQn:Neut
Synonyms: anticorpo Microbiologia Punto nel tempo (episodio) Siero Test di neutralizzazione Titolo Virus della rabbia
nl-NL Dutch (Netherlands) rabiësvirus As.neutraliserend:titer:moment:serum:semikwantitatief:neutralisatietest
Synonyms: antistof; antilichaam hondsdolheidsvirus; Rabies lyssavirus; RABV
pl-PL Polish (Poland) Wirus wścieklizny Ab.Neutralizujące:miano:punkt w czasie:surowica:półilościowy:test neutralizacji
Synonyms: Przeciwciała do wirusa wścieklizny Przeciwciała neutralizujące do wirusa wścieklizny
pt-BR Portuguese (Brazil) Raiva vírus Ac:Título:Pt:Soro:Qn:Teste de neutralização
Synonyms: ; RAcV; Lyssavirus; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Nt; NT; Neutralization test; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Microbiology
zh-CN Chinese (China) 狂犬病病毒 抗体.中和:滴定度:时间点:血清:半定量型:中和试验
Synonyms: Ab;自身抗体 RABV Ab RABV 抗体 RABV;儿犬病;恐水病;狂犬病;狂犬病毒;麻痹型狂犬病 中和试验;中和抗体;中和 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 狂犬病毒 Ab 狂犬病毒抗体 狂犬病病毒 Ab

Example Units

Unit Source
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=43980-2