LOINC
Version 2.73

46244-0Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation identified by Molecular methodActive

Term Description

Mycobacterium rpoB region gene mutation for Rifampim resistance
Source: Regenstrief LOINC

Part Description

LP267160-2   Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP.[PMID:26038512] Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation identified
Property
Prid
Time
Pt
System
Isolate/Specimen
Scale
Nom
Method
Molgen

Additional Names

Short Name
MTB cmplx rpoB RIF mut Islt/Spm
Display Name
M. tuberculosis complex rpoB gene rifAMPin resistance mutation identified Molgen Nom (Islt/Spec)
Consumer Name Alpha
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation test

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.19
Last Updated
Version 2.67
Change Reason
Release 2.67: COMPONENT: Updated Component to reflect that rpoB is a native gene in which a mutation causes rifampin resistance [Approved by LOINC Laboratory Committee in June 2018].; METHOD_TYP: Update Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].; SYSTEM: Updated System from "Isolate" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

zh-CNChinese (China)
结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变 已鉴定的:存在与否或特征标识:时间点:分离株/标本:名义型:分子遗传学类实验室方法
nl-NLDutch (Netherlands)
Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie geïdentificeerd:identificator:moment:isolaat of monster:nominaal:moleculair genetisch onderzoek
fr-FRFrench (France)
Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation identifiée:Identification:Ponctuel:Isolat/échantillon:Résultat nominal:Biologie moléculaire
de-DEGerman (Germany)
Mycobacterium tuberculosis-Komplex rpoB-Gen Rifampicinresistenzmutation identifiziert:Nachweis oder Identität:Zeitpunkt:Isolat oder Probenmaterial:Nominal:Molekulargenetisch
it-ITItalian (Italy)
Mycobacterium tuberculosis complex, gene rpoB rifampina resistente , identificato:Prid:Pt:Isolato/Campione:Nom:Molgen
pt-BRPortuguese (Brazil)
Mycobacterium tuberculosis DNA.rpoB:Ident:Pt:Isolado:Nom:Sonda com limite de detecção da amplificação de alvo
es-MXSpanish (Mexico)
Se identificó una mutación de resistencia a rifAMPina del complejo de Mycobacterium tuberculosis rpoB:Presencia o identidad:Punto temporal:Aislado o espécimen:Nominal:Genética molecular
es-ESSpanish (Spain)
Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis identificado:Presencia o identidad:Punto temporal:Muestra aislada:Nom:Genética molecular

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=46244-0