47303-3
Anaplastic lymphoma kinase Ag [Presence] in Tissue by Immune stain
Active
Part Description
LP61603-4 Anaplastic lymphoma kinase
Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.
The ALK gene can be oncogenic in two ways - first, by forming a fusion gene with any of several other genes, and second, with mutations of the actual DNA code for the gene itself.
The 2;5 chromosomal translocation is associated with approximately 60% anaplastic large-cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. The product of the NPM-ALK fusion gene is oncogenic.
The EML4-ALK fusion gene is responsible for approximately 3-5% of non-small-cell lung cancer(NSCLC). The vast majority of cases are adenocarcinomas. The standard test used to detect this gene in tumor samples is fluorescence in situ hybridization (FISH), but other techniques such as immunohistochemistry (IHC) and reverse-transcriptase PCR (RT-PCR) can also be used to detect lung cancers with an ALK gene fusion. ALK lung cancers are found in patients of all ages, although on average these patients may be somewhat younger. ALK lung cancers are more common in never or light cigarette smokers, but a significant number of patients with this disease are current or former cigarette smokers.
Recent study shows that mutation of ALK "are linked to 10-15% of "neuroblastoma", a deadly childhood form of cancer.
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Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Anaplastic lymphoma kinase Ag
- Property
- PrThr
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- Immune stain
Additional Names
- Long Common Name
- Anaplastic lymphoma kinase Ag [Presence] in Tissue by Immune stain
- Short Name
- ALK Ag Tiss Ql ImStn
- Display Name
- Anaplastic lymphoma kinase Ag Immune stain Ql (Tiss)
- Consumer Name Alpha Get Info
- Anaplastic lymphoma kinase antigen, Tissue
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.19
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 11488
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Κινάση αναπλαστικού λυμφώματος Αντιγόνο: Synonyms: PrThr Κινάση αναπλαστικού λυμφώματος |
| es-ES | Spanish (Spain) | Proteína quinasa de linfoma anaplásico Antígeno: |
| es-MX | Spanish (Mexico) | Linfoma anaplásico quinasa Ag: |
| fr-CA | French (Canada) | Kinase de lymphome anaplasique, Ag: |
| fr-FR | French (France) | Anaplasic lymphoma kinase antigène: |
| fr-BE | French (Belgium) | Kinase de lymphome anaplasique Ag: Synonyms: Antigène Coloration. Méthode mmunologique |
| it-IT | Italian (Italy) | Linfoma anaplastico chinasi, Ag: Synonyms: Chinasi del linfoma anaplastico Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | anaplastisch lymfoomkinase Ag: Synonyms: antigeen |
| pt-BR | Portuguese (Brazil) | Quinase do linfoma anaplástico Ag: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Анапластическая лимфомная киназа Аг: Synonyms: Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | Anaplastik lemfoma kinaz Ag: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 间变型淋巴瘤激酶 抗原: Synonyms: Ag ALK Ag ALK 抗原 ALK 蛋白; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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