48634-0

Coproporphyrin/Creatinine [Mass Ratio] in 24 hour Urine

Active

Part Descriptions

LP15151-1   Coproporphyrin
4 carboxyl groups Source: Regenstrief Institute

LP15151-1   Coproporphyrin
Porphyrins build up among patients with hereditary enzyme disorders known as porphyrias. Porphyrias affect the heme biosynthetic pathway and cause increased urine excretion of porphyrinogens, by-products known as porphyrins and porphyrinogen precursors-including delta aminolevulinic acid (ALA) and porphobilinogen (PBG). Coproporphyrin and uroporphyrin excretion in urine is markedly increased during acute attacks of hereditary coproporphyria. Increased uroporphyrinogen, uroporphyrin, and coproporphyrin excretion occurs in porphyria cutanea tarda. Increased coproporphyrin excretion alone lacks specificity and sensitivity for lead testing and is likely to occur secondary to other diseases. Information from LOINC partner 1 and Jacobs and DeMott Laboratory Test Handbook, 5th edition, DS Jacobs, WR DeMott and DK Oxley, 2001. 2007 08 06. Source: Regenstrief Institute

LP15151-1   Coproporphyrin
Part of porphyrin fractionation testing useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria. Such patients typically will present with profound elevations of porphyrin analytes (e.g. > 5-fold) during acute episodes. Moderate elevations (e.g. < 3-fold) are more often due to medications or environmental factors. Source: Regenstrief LOINC

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component

Coproporphyrin/Creatinine

Property

MRto

Time

24H

System

Urine

Scale

Qn

Method

Additional Names

Short Name

Copro/Creat 24h Ur

Display Name

Coproporphyrin/Creatinine (24H U) [Mass ratio]

Consumer Name Alpha Get Info

Coproporphyrin/Creatinine, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.21

Last Updated

Version 2.42

Order vs. Observation

Both

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 1 day
• 24 hours
• 24HR
• Chemistry
• Copro
• Coproporph
• Coproporphyrins
• CR
• Crea
• Creat
• Mass concentration ratio
• Mass ratio
• MCRto
• QNT
• Quan
• Quant
• Quantitative
• Tetracarboxyl porphyrin
• Tetracarboxylporphyrin
• Tetracarboxylporphyrins
• Tetracarboxyporphyrin
• UA
• UCr
• UR
• Urn

Example Units

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.