49113-4

ZAP70 Ag [Presence] in Tissue by Immune stain

Active

Part Description

LP40299-7 ZAP70
ZAP-70 is an abbreviation for Zeta-chain-associated protein kinase 70 (70 is the molecular weight in kDa). The protein is a member in the protein-tyrosine kinase family. ZAP-70 is normally expressed in T cells and natural killer cells and has a critical role in the initiation of T-cell signaling.

ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). DNA analysis has distinguished two major types of CLL, with different survival times. CLL that is positive for the marker ZAP-70 has an average survival of 8 years. CLL that is negative for ZAP-70 has an average survival of more than 25 years. Many patients, especially older ones, with slowly progressing disease can be reassured and may not need any treatment in their lifetimes.

In systemic lupus erythematosis, the Zap-70 receptor pathway is missing and Syk takes its place.

ZAP70 deficiency results in a form of immune deficiency. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name: ZAP70 Ag:PrThr:Pt:Tiss:Ord:Immune stain
Long Common Name: ZAP70 Ag [Presence] in Tissue by Immune stain
Short Name: ZAP70 Ag Tiss Ql ImStn
Display Name: ZAP70 Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info: ZAP70 antigen, Tissue

Part Model Get Info

Component
ZAP70 Ag
LP64184-2
- Analyte
  ZAP70 Ag
  LP64184-2
  - Component Numerator
    ZAP70 Ag
    LP64184-2
    - Component Numerator Core
      ZAP70
      LP40299-7
    - Component Numerator Core Suffix
      Ag
      LP20666-1
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Tiss
LP7641-6
- System Core
  Tiss
  LP7641-6
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Immune stain
LP6333-1

Basic Attributes

Class: PATH
Type: Laboratory
First Released: Version 2.21
Last Updated: Version 2.73 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 17107

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	ZAP70 Ag:Přítomnost nebo práh:Časový bod:Tkáně a stěry:Ordinální:Imunobarvení
el-GR	Greek (Greece)	ZAP70 Αντιγόνο:PrThr:Pt:Ιστός:Ord:Ανοσολογική χρώση Synonyms: Ord PATH PrThr Pt ZAP70 Ανοσολογική χρώση Αντιγόνο Ιστός
es-ES	Spanish (Spain)	ZAP70 Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX	Spanish (Mexico)	ZAP70 Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
et-EE	Estonian (Estonia)	ZAP70 antigeen:PrThr:Pt:Tis:Ord:Immuunvärv Synonyms: Järgarvuline Juhuslik Kude
fr-CA	French (Canada)	ZAP70, Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FR	French (France)	ZAP70 Ag:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
fr-BE	French (Belgium)	ZAP70 Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique Synonyms: Antigène Coloration. Méthode mmunologique
it-IT	Italian (Italy)	ZAP70, Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NL	Dutch (Netherlands)	ZAP70 Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring Synonyms: antigeen
pl-PL	Polish (Poland)	ZAP70 Ag:granica wykrywalności:punkt w czasie:tkanka i rozmazy:uporządkowany:barwienie immunohistochemiczne Synonyms: Kinaza ZAP-70
pt-BR	Portuguese (Brazil)	ZAP70 Ag:ACnc:Pt:Tecido:Ord:Imunocoloração Synonyms: ZAP-70; Zeta-associated protein 70; Arbitrary concentration; Point in time; Random; Tissue; Ql; Ordinal; QL; Qualitative; Qual; Screen; ImStn; Immunostain; Immunohistochemical stain; IHC; Antigen; Antigens; Imun; Imune; Imm; PATHOLOGY
ru-RU	Russian (Russian Federation)	ZAP70 Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TR	Turkish (Turkey)	ZAP70 Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama Synonyms: Antijen Mevcut
zh-CN	Chinese (China)	ZAP70 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法 Synonyms: Ag ZAP70 Ag ZAP-70;Zeta相关蛋白 70;Zeta-相关蛋白 70 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片染法染色方法染色法着色着色方法着色法

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.