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Part Description

LP68363-8   Alpha synuclein
Alpha-synuclein also known as SNCA is a protein that, in humans, is encoded by the SNCA gene. An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, is shown to be a fragment of its precursor protein, NACP, by cloning of the full-length cDNA. Later, NACP turned out to be a human homologue of Torpedo synuclein. Therefore, NACP is also referred to as human alpha-synuclein.

Normally an unstructured soluble protein, alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. These disorders are known as synucleinopathies. Alpha-synuclein is the primary structural component of Lewy body fibrils. Occasionally, Lewy bodies contain tau protein, however, alpha-synuclein and tau constitute two distinctive subsets of filaments in the same inclusion bodies. Alpha-synuclein pathology is also found in both sporadic and familial cases with Alzheimer's disease. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Alpha synuclein Ag:PrThr:Pt:Tiss:Ord:Immune stain
Long Common Name
Alpha synuclein Ag [Presence] in Tissue by Immune stain
Short Name
a-synuclein Ag Tiss Ql ImStn
Display Name
Alpha synuclein Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
Alpha synuclein antigen, Tissue

Part Model Get Info

  • Component
    Alpha synuclein Ag
    LP64419-2
    • Analyte
      Alpha synuclein Ag
      LP64419-2
      • Component Numerator
        Alpha synuclein Ag
        LP64419-2
        • Component Numerator Core
          Alpha synuclein
          LP68363-8
        • Component Numerator Core Suffix
          Ag
          LP20666-1
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Immune stain
    LP6333-1

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.22
Last Updated
Version 2.56 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Alfa-synuklein Ag:Přítomnost nebo práh:Časový bod:Tkáně a stěry:Ordinální:Imunobarvení
el-GRGreek (Greece)Α-συνουκλεΐνη Αντιγόνο:PrThr:Pt:Ιστός:Ord:Ανοσολογική χρώση
Synonyms: Ord PATH PrThr Pt Ανοσολογική χρώση Αντιγόνο Α-συνουκλεΐνη Ιστός
es-ESSpanish (Spain)Alfa-sinucleina Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MXSpanish (Mexico)Alfa sinucleína Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
et-EEEstonian (Estonia)Alfa sünukleiin antigeen:PrThr:Pt:Tis:Ord:Immuunvärv
Synonyms: Järgarvuline Juhuslik Kude
fr-FRFrench (France)Alpha-synucléine Ag:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
fr-BEFrench (Belgium)Alpha synucléine Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
Synonyms: Antigène Coloration. Méthode mmunologique
it-ITItalian (Italy)Alfa sinucleina, Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NLDutch (Netherlands)alfa-synucleïne Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
Synonyms: antigeen
pl-PLPolish (Poland)Alfa synukleina Ag:granica wykrywalności:punkt w czasie:tkanka i rozmazy:uporządkowany:barwienie immunohistochemiczne
Synonyms: Antygen alfa synukleiny ASN
pt-BRPortuguese (Brazil)Alfa sinucleina Ag:ACnc:Pt:Tecido:Ord:Imunocoloração
Synonyms: ; a-synuclein; Arbitrary concentration; Point in time; Random; Tissue; Ql; Ordinal; QL; Qualitative; Qual; Screen; ImStn; Immunostain; Immunohistochemical stain; IHC; Antigen; Antigens; Imun; Imune; Imm; Alfa; PATHOLOGY
ru-RURussian (Russian Federation)Альфа синуклеин Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TRTurkish (Turkey)Alfa sinüklein Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama
Synonyms: Antijen Mevcut
zh-CNChinese (China)Alpha 突触核蛋白 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: Ag Alpha 核突触蛋白 Ag Alpha 核突触蛋白抗原 Alpha 突触素 Ag α α-核突触蛋白 Ag α-核突触蛋白抗原 α-突触核蛋白;α-Synuclein;α-Syn;帕金森氏病 α-突触素 Ag α-突触素抗原 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 核突触蛋白-α Ag 核突触蛋白-α抗原 着色 着色方法 着色法 突触素-1 Ag 突触素-1 抗原 阿尔法

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=49456-7