49476-5
Cyclooxygenase 2 Ag [Presence] in Tissue by Immune stain
Active
Part Description
LP64434-1 Cyclooxygenase 2
Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.
Cyclooxygenase-2 is unexpressed under normal conditions in most cells, but elevated levels are found during inflammation. Since COX-2 is generally expressed only in cells where prostaglandins are upregulated (e.g., during inflammation), drug-candidates that selectively inhibit COX-2 are thought to show fewer side-effects.
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin production by cyclooxygenases (COX) 1 and 2. NSAIDs selective for inhibition of COX-2 are less likely than traditional drugs to cause gastrointenstinal adverse effects, but could cause cardiovascular events, such as heart failure, myocardial infarction, and stroke. Studies with human pharmacology and genetics, genetically manipulated rodents, and other animal models and randomized trials indicate that this is due to suppression of COX-2-dependent cardioprotective prostaglandins, prostacyclin in particular
NSAID (non-specific inhibitor of COX-2) Flurbiprofen (green) bound to COX-2. Flurbiprofen is stabilized via hydrophobic interactions and polar interactions (Tyr-355 and Arg-120).[19]
The expression of COX-2 is upregulated in many cancers. The overexpression of COX-2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer.
The mutant allele PTGS2 5939C carriers among the Han Chinese population have been shown to have a higher risk of gastric cancer. In addition, a connection was found between Helicobacter pylori infection and the presence of the 5939C allele.
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Source: Wikipedia,
Wikipedia
LOINC Names Get Info
- Fully-Specified Name
- Cyclooxygenase 2 Ag:
PrThr: Pt: Tiss: Ord: Immune stain - Long Common Name
- Cyclooxygenase 2 Ag [Presence] in Tissue by Immune stain
- Short Name
- COX2 Ag Tiss Ql ImStn
- Display Name
- Cyclooxygenase 2 Ag Immune stain Ql (Tiss)
- Consumer Name Alpha Get Info
- Cyclooxygenase 2 antigen, Tissue
Part Model Get Info
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.22
- Last Updated
- Version 2.56 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Cyklooxygenáza 2 Ag: |
| el-GR | Greek (Greece) | Κυκλοοξυγενάση 2 Αντιγόνο: Synonyms: Ord PATH PrThr Pt Ανοσολογική χρώση Αντιγόνο Ιστός Κυκλοοξυγενάση 2 |
| es-ES | Spanish (Spain) | Ciclooxigenasa2 Antígeno: |
| es-MX | Spanish (Mexico) | Ciclooxigenasa 2 Ag: |
| et-EE | Estonian (Estonia) | Tsüklooksügenaas 2 antigeen: Synonyms: Järgarvuline Juhuslik Kude |
| fr-FR | French (France) | Cyclo-oxygénase 2 Ag: |
| fr-BE | French (Belgium) | Cyclooxygenase 2 Ag: Synonyms: Antigène Coloration. Méthode mmunologique |
| it-IT | Italian (Italy) | Cicloossigenasi 2, Ag: Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | cyclooxygenase 2 Ag: Synonyms: antigeen |
| pl-PL | Polish (Poland) | Cyklooksygenaza 2 Ag: Synonyms: COX-2 |
| pt-BR | Portuguese (Brazil) | Ciclooxigenase 2 Ag: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Циклооксигеназа 2 Аг: Synonyms: Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | Siklooksijenaz 2 Ag: Synonyms: Antijen Mevcut |
| zh-CN | Chinese (China) | 环氧化酶 2 抗原: Synonyms: Ⅱ Ag COX2 Ag COX-2 Ag COX2 抗原 COX-2 抗原 COX2; |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://