49479-9

FOXP3 Ag [Presence] in Tissue by Immune stain

Active

Part Description

LP64437-4 FOXP3
FOXP3 (forkhead box P3) also known as scurfin is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator in the development and function of regulatory T cells.

While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription.

In human disease, alterations in numbers of regulatory T cells - and in particular those that express Foxp3 - are found in a number of disease states. For example, patients with tumors have a local relative excess of Foxp3 positive T cells which inhibits the body's ability to suppress the formation of cancerous cells. Conversely, patients with an autoimmune disease such as systemic lupus erythematosus (SLE) have a relative dysfunction of Foxp3 positive cells. The Foxp3 gene is also mutated in the X-linked IPEX syndrome (Immunodysregulation, Polyendocrinopathy, and Enteropathy, X-linked). These mutations were in the forkhead domain of FOXP3, indicating that the mutations may disrupt critical DNA interactions. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name: FOXP3 Ag:PrThr:Pt:Tiss:Ord:Immune stain
Long Common Name: FOXP3 Ag [Presence] in Tissue by Immune stain
Short Name: FOXP3 Ag Tiss Ql ImStn
Display Name: FOXP3 Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info: FOXP3 antigen, Tissue

Part Model Get Info

Component
FOXP3 Ag
LP64905-0
- Analyte
  FOXP3 Ag
  LP64905-0
  - Component Numerator
    FOXP3 Ag
    LP64905-0
    - Component Numerator Core
      FOXP3
      LP64437-4
    - Component Numerator Core Suffix
      Ag
      LP20666-1
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Tiss
LP7641-6
- System Core
  Tiss
  LP7641-6
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Immune stain
LP6333-1

Basic Attributes

Class: PATH
Type: Laboratory
First Released: Version 2.22
Last Updated: Version 2.56 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	FOXP3 Ag:Přítomnost nebo práh:Časový bod:Tkáně a stěry:Ordinální:Imunobarvení
el-GR	Greek (Greece)	FOXP3 Αντιγόνο:PrThr:Pt:Ιστός:Ord:Ανοσολογική χρώση Synonyms: FOXP3 Ord PATH PrThr Pt Ανοσολογική χρώση Αντιγόνο Ιστός
es-ES	Spanish (Spain)	FOXP3 Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX	Spanish (Mexico)	FOXP3 Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
et-EE	Estonian (Estonia)	FOXP3 antigeen:PrThr:Pt:Tis:Ord:Immuunvärv Synonyms: Järgarvuline Juhuslik Kude
fr-CA	French (Canada)	FOXP3, Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FR	French (France)	FOXP3 Ag:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
fr-BE	French (Belgium)	FOXP3 Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique Synonyms: Antigène Coloration. Méthode mmunologique
it-IT	Italian (Italy)	FOXP3, Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NL	Dutch (Netherlands)	FOXP3 Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring Synonyms: antigeen
pl-PL	Polish (Poland)	FOXP3 Ag:granica wykrywalności:punkt w czasie:tkanka i rozmazy:uporządkowany:barwienie immunohistochemiczne Synonyms: Antygen czynnika transkrypcyjnego FOXP3 Czynnik transkrypcyjny FOXP3
pt-BR	Portuguese (Brazil)	FOXP3 Ag:ACnc:Pt:Tecido:Ord:Imunocoloração Synonyms: Forkhead box P3; Arbitrary concentration; Point in time; Random; Tissue; Ql; Ordinal; QL; Qualitative; Qual; Screen; ImStn; Immunostain; Immunohistochemical stain; IHC; Antigen; Antigens; Imun; Imune; Imm; PATHOLOGY
ru-RU	Russian (Russian Federation)	FOXP3 Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TR	Turkish (Turkey)	FOXP3 Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama Synonyms: Antijen Mevcut
zh-CN	Chinese (China)	FOXP3 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法 Synonyms: Ag FOXP3 Ag IPEX;JM2;Scurfin;叉头框 P3;叉头框 P3（Forkhead box P3，FOXP3）;叉头盒 P3 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片染法染色方法染色法着色着色方法着色法

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.