Version 2.78

Part Description

LP31804-5   Nucleosome
The nucleosome is the structural unit of chromatin and consists of a segment of dsDNA coiled around a histone core. Anti-chromatin autoantibodies, such as those found in patients with systemic lupus erythematosus (SLE) fall in to two categories: those directed against individual components of chromatin, such as DNA and histone, and those directed against the intact nucleosome. Traditionally anti-dsDNA antibodies have been among the ones used for diagnosis and monitoring of SLE, however, studies have shown that for some patients, the nucleosome is the primary antigen in SLE, and anti-nucleosome antibodies may provide a better reflection of disease activity. A subset of patients who are positive for anti-nucleosome antibodies but negative for anti-dsDNA antibodies may have a milder course of SLE that does not involve the kidneys. PMID: 25193804 Source: Regenstrief LOINC, PMID: 25193804

Fully-Specified Name

Component
Nucleosome Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method

Additional Names

Short Name
Nucleosome Ab Ser Ql
Display Name
Nucleosome Ab Ql (S)
Consumer Name Alpha Get Info
Nucleosome antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.24
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG21386-4 Nucleosome Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Nukleosomen-AK ql.
de-DE German (Germany) Nukleosom Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:
es-ES Spanish (Spain) Nucleosoma Anticuerpos:PrThr:Punto temporal:Suero:Ord:
es-MX Spanish (Mexico) Ab nucleosoma:Presencia o umbral:Punto temporal:Suero:Ordinal:
et-EE Estonian (Estonia) Nukleosoom antikehad:PrThr:Pt:S:Ord:
Synonyms: Järgarvuline Juhuslik Seerum
fr-CA French (Canada) Nucléosome, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:
fr-FR French (France) Nucléosomes anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:
fr-BE French (Belgium) Nucléosome Ac:PrThr:Temps ponctuel:Sérum:Ordinal:
Synonyms: Anticorps
it-IT Italian (Italy) Nucleosoma Ab:PrThr:Pt:Siero:Ord:
Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) nucleosoom As:aanwezigheid:moment:serum:ordinaal:
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Nukleosom Ab:granica wykrywalności:punkt w czasie:surowica:półilościowy:
Synonyms: Przeciwciała do nukleosomów
pt-BR Portuguese (Brazil) Nucleossomo Ac:ACnc:Pt:Soro:Ord:
Synonyms: Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU Russian (Russian Federation) Нуклеосома Ат:PrThr:ТчкВрм:Сыв:Пор:
Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Nükleozom Ab:MevcEşik:Zmlı:Ser:Srl:
Synonyms: Ak Mevcut
zh-CN Chinese (China) 核小体 抗体:存在情况或阈值:时间点:血清:序数型:
Synonyms: Ab;自身抗体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 核小体 Ab 核粒 核粒 Ab 核粒抗体 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53015-4