5349-6

SCL-70 extractable nuclear Ab [Presence] in Serum by Immune diffusion (ID)

Active

Part Description

LP16758-2 SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

LOINC Names Get Info

Fully-Specified Name: SCL-70 extractable nuclear Ab:PrThr:Pt:Ser:Ord:Immune diffusion
Long Common Name: SCL-70 extractable nuclear Ab [Presence] in Serum by Immune diffusion (ID)
Short Name: ENA Scl70 Ab Ser Ql ID
Display Name: SCL-70 extractable nuclear Ab Immune diff Ql (S)
Consumer Name Alpha Get Info: SCL-70 extractable nuclear antibody, Blood

Part Model Get Info

Component
SCL-70 extractable nuclear Ab
LP39721-3
- Analyte
  SCL-70 extractable nuclear Ab
  LP39721-3
  - Component Numerator
    SCL-70 extractable nuclear Ab
    LP39721-3
    - Component Numerator Core
      SCL-70 extractable nuclear
      LP16758-2
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Immune diffusion
LP6322-4

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 1.0
Last Updated: Version 2.73 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 18427

Member of these Groups Get Info

LOINC Group	Group Name
LG5141-9	SCL-70 extractable nuclear Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Antinukleární protilátky SCL-70 extrahovatelné:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Imunodifuze (ID)
de-DE	German (Germany)	SCL-70 extrahierbarer nukleärer Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immundiffusion Synonyms: Scl-70
el-GR	Greek (Greece)	Εκχυλίσιμα πυρηνικά SCL-70 Αντίσωμα:PrThr:Pt:Ορός:Ord:Ανοσοδιάχυση Synonyms: Ord PrThr Pt SERO Ανοσοδιάχυση Αντίσωμα Εκχυλίσιμα πυρηνικά Εκχυλίσιμα πυρηνικά SCL-70 Ορός Πυρηνικό
es-AR	Spanish (Argentina)	SCL-70 nuclear extraíble:concentración arbitraria:punto en el tiempo:suero:ordinal:difusión inmunitaria
es-ES	Spanish (Spain)	Antígeno nuclear extraíble SCL-70 Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunodifusión
es-MX	Spanish (Mexico)	Ab nuclear extraíble SCL-70:Presencia o umbral:Punto temporal:Suero:Ordinal:Difusión inmunitaria (ID)
fr-CA	French (Canada)	SCL-70 nucléaire soluble, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunodiffusion
fr-FR	French (France)	SCL-70 Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunodiffusion
fr-BE	French (Belgium)	SCL-70 nucléaire soluble Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunodiffusion Synonyms: Anticorps
it-IT	Italian (Italy)	Nucleare estraibile SCL-70 Ab:PrThr:Pt:Siero:Ord:Immuno diffusione Synonyms: anticorpo ENA Immuno diffusione (ID) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
ko-KR	Korean (Korea, Republic Of)	SCL-70 추출성 핵 항체:임의농도:검사시점:혈청:순위척도:면역 확산
nl-NL	Dutch (Netherlands)	SCL-70 extraheerbare nucleaire As:aanwezigheid:moment:serum:ordinaal:immunodiffusie Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	SCL-70 rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:surowica:uporządkowany:immunodyfuzja Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
pt-BR	Portuguese (Brazil)	SCL-70 Ac:ACnc:Pt:Soro:Ord:Imunodifusão Synonyms: ; ENA Scl70; Scleroderma Ac; ANA; ANF; NA; Antinuclear antibody; Nuc; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; ID; Immunodiff; Immunodiffusion; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Imun; Imune; Imm; Serology
ru-RU	Russian (Russian Federation)	SCL-70 экстрагируемый ядерный Ат:PrThr:ТчкВрм:Сыв:Пор:Иммунодиффузия Synonyms: Антитело Иммунодиффузия (ИД) Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	SCL-70 özütlenebilir nükleer Ab:MevcEşik:Zmlı:Ser:Srl:İmmün difüzyon Synonyms: Ak Çekirdek Mevcut
zh-CN	Chinese (China)	SCL-70 可提取性核抗体:存在情况或阈值:时间点:血清:序数型:免疫扩散法 Synonyms: Ab;自身抗体 ANA ENA Ab ENA SCL-70 Ab ENA SCL-70 抗体 ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ag Ab SCL-70 可提取性核抗原抗体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫扩散可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 抗体可提取性核抗原之抗体存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）抗 ENA 抗可提取性核 Ag 抗可提取性核抗原抗核 Ab 抗核抗体抗核抗体（Antinuclear antibody，ANA）时刻;随机;随意;瞬间核;胞核皮硬化症硬皮病硬皮病（Scleroderma，SCL）硬皮症细胞核 Ab 胞核 Ab 胞核抗体血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.