Version 2.78

Part Description

LP19732-4   KRAS gene
The KRAS gene (Kirsten rat sarcoma viral oncogene homolog) [HGNC Gene ID:6407] is located on chromosome 12p12.1. This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008] [NCBI Gene ID:3845] Source: National Center for Biotechnology Information (NCBI) Gene

Fully-Specified Name

Component
KRAS gene targeted mutation analysis
Property
Prid
Time
Pt
System
Bone mar
Scale
Nom
Method
Molgen

Additional Names

Short Name
KRAS gene Mut Anl Mar
Display Name
KRAS gene targeted mutation analysis Molgen Nom (BM)
Consumer Name Alpha Get Info
KRAS gene targeted mutation analysis, Bone marrow

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.63
Change Reason
Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: KRAS Mutationsanalyse /KM
es-ES Spanish (Spain) Gen KRAS Analisis de mutaciones:Presencia o identidad:Punto temporal:Médula ósea:Nom:Genética molecular
es-MX Spanish (Mexico) Análisis de mutaciones dirigidas al gen KRAS:Presencia o identidad:Punto temporal:Médula ósea:Nominal:Genética molecular
fr-FR French (France) KRAS gène mutation cible trouvée:Identification:Ponctuel:Moelle osseuse:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) KRAS, gene analisi di mutazione mirata:Prid:Pt:Mid oss:Nom:Molgen
Synonyms: Gene KRAS Genetica molecolare Midollo osseo Mutazione genica Patologia molecolare Presenza o Identità Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) KRAS-gen doelgerichte mutatie-analyse:identificator:moment:beenmerg:nominaal:moleculair genetisch onderzoek
Synonyms: KRAS gen molgen targeted
pt-BR Portuguese (Brazil) KRAS análise de mutação genética:Ident:Pt:MedOssea:Nom:Genética molecular
Synonyms: Kirsten rat sarcoma virus 2; RASK2; Oncogene KRAS2; V-KI-RAS1 pseudogene; KRAS1P; Oncogene KRAS1; Kirsten ras 1; RASK1; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; Identity or presence; Point in time; Random; BM; Bone marrow; BON; Nominal; PCR; Molecular genetics; Mut Anal; Mutations; MOLPATH.MUTATIONS; MOLPATH.MUTATIONS; Molecular pathology
ru-RU Russian (Russian Federation) KRAS ген исследование на мутацию:ПрИд:ТчкВрм:Костный мозг:Ном:МолГен
Synonyms: Номинальный;Именной Присутствие или Идентификация Точка во времени;Момент
tr-TR Turkish (Turkey) KRAS geni Mutasyon analizi:MevcKimlik:Zmlı:Kem il:Snf:Molgen
zh-CN Chinese (China) KRAS2 基因 突变分析:存在与否或特征标识:时间点:骨髓:名义型:分子遗传学类实验室方法
Synonyms: Kirsten 大鼠肉瘤病毒 2;RASK1;RASK2;V-KI-RAS1 假基因;V-KI-RAS1 拟基因;v-Ki-ras2 Kirsten 大鼠肉瘤 2 病毒性癌基因同源基因;v-Ki-ras2 Kirsten 大鼠肉瘤 2 病毒性致癌基因同源基因;v-Ki-ras2 Kirsten 大鼠肉瘤 2 病毒癌基因同源基因;癌基因 KRAS1;癌基因 KRAS2;致癌基因 KRAS1;致癌基因 KRAS2 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 基因突变分析 存在;存在与否;特征标识;身份;身份标识 时刻;随机;随意;瞬间 遗传基因;遗传因子;吉恩;生物基因 骨骼;骨头 髓

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53620-1