Version 2.78

Part Description

LP71684-2   Centromere protein B Ab
Major centromere autoantigen B, also known as centromere protein B or CENP-B, is encoded by the CENPB gene located on chromosome 20p13. CENP-B interacts with chromosomal centromeric heterochromatin and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. [UniProt: P07199] CENP-B plays a direct role in stablizing CENP-C, which is a kinetochore assembly nucleator, and recruiting CENP-A, which marks and maintains centromere position. Chromosomes that have centromeres without bound CENP-B, including the human Y chromosome, are more likely to missegregate at much higher rates than chromosomes with CENP-B containing centromeres. PMID: 25942623 Autoantibodies to both CENP-A and CENP-B are markers for scleroderma and other rheumatic diseases. PMID: 17210244 Source: Regenstrief LOINC, UniProt: P07199

Fully-Specified Name

Component
Centromere protein B Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method

Additional Names

Short Name
Centromere B Ab Ser Ql
Display Name
Centromere protein B Ab Ql (S)
Consumer Name Alpha Get Info
Centromere Protein B antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
5206

Member of these Groups Get Info

LOINC Group Group Name
LG21820-2 Centromere protein B Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: CENP-B-AK ql.
de-DE German (Germany) Zentromerprotein B Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:
Synonyms: CENP
es-ES Spanish (Spain) Proteína B del centrómero Anticuerpos:PrThr:Punto temporal:Suero:Ord:
es-MX Spanish (Mexico) Centrómero de proteína B Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:
et-EE Estonian (Estonia) Tsentromeer B vastased antikehad:PrThr:Pt:S:Ord:
Synonyms: Järgarvuline Juhuslik Seerum
fr-CA French (Canada) Centromère protéine B, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:
fr-FR French (France) Centromère protéine B anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:
fr-BE French (Belgium) Centromère. Protéine B Ac:PrThr:Temps ponctuel:Sérum:Ordinal:
Synonyms: Anticorps
it-IT Italian (Italy) Centromero, proteina B Ab:PrThr:Pt:Siero:Ord:
Synonyms: anticorpo Presenza o Soglia Proteina B del centromero Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) centromeereiwit B As:aanwezigheid:moment:serum:ordinaal:
Synonyms: antistof; antilichaam
pt-BR Portuguese (Brazil) Proteína B do Centrômero Ac:ACnc:Pt:Soro:Ord:
Synonyms: ; Prot; PR; Centromere B; CENP-B; CENPB; CRST syndrome; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU Russian (Russian Federation) Центромерный протеин B Ат:PrThr:ТчкВрм:Сыв:Пор:
Synonyms: Антитело Белок Порядковый Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Sentromer protein B Ab:MevcEşik:Zmlı:Ser:Srl:
Synonyms: Ak Mevcut
zh-CN Chinese (China) 着丝点蛋白 B 抗体:存在情况或阈值:时间点:血清:序数型:
Synonyms: Ab;自身抗体 B 型 B型抗体 CRST 综合征;着丝粒;动粒 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 着丝粒蛋白 B;动粒蛋白 B 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53981-7