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Term Description

This entity has two names: "nucleolar organizing region (NOR) 90" versus "human upstream binding factor (hUBF)". Both names are right, and the literature looking for the antibody in autoimmune patients almost uniformly includes both names and the historical context. NOR90 stuck because it was called that by the author of the original finding in autoimmune patients (Rodriguez-Sanchez, et al, 1987), but a few years later (1994), the antigen was found to be identical to already characterized hUBF. So we are stuck with the 2 names. hUBF is more technically specific, and at least one recent review calls it "anti-hUBF, formerly anti-NOR 90" (Journal of Dermatology 2010; 37: 42-53). So we will use that as its primary name.

Part Description

LP71704-8   Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. PMID: 25965800 Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. PMID: 20175839 Source: Regenstrief LOINC, PMID: 20175839

LOINC Names Get Info

Fully-Specified Name
Human upstream binding factor Ab:Titr:Pt:Ser:SemiQn:IF
Long Common Name
Human upstream binding factor Ab [Titer] in Serum by Immunofluorescence
Short Name
hUBF Ab Titr Ser IF
Display Name
Human upstream binding factor Ab IF (S) [Titer]
Consumer Name Alpha Get Info
Human upstream binding factor antibody, Blood

Part Model Get Info

  • Component
    Human upstream binding factor Ab
    LP71696-6
    • Analyte
      Human upstream binding factor Ab
      LP71696-6
      • Component Numerator
        Human upstream binding factor Ab
        LP71696-6
        • Component Numerator Core
          Human upstream binding factor
          LP71704-8
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Titr
    LP6881-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    IF
    LP6323-2

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.75 (MAJ)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Lidský faktor UBF Ab:Arbitrární koncentrace (titr):Časový bod:Sérum:Semikvantitativní:Imunofluoresecence (IF)
de-DEGerman (Germany)Human upstream binding factor Ak:Titer:Zeitpunkt:Serum:Semiquantitativ:Immunfluoreszenztest
Synonyms: NOR-90
el-GRGreek (Greece)Ανθρώπινος παράγοντας δέσμευσης ανάντη Αντίσωμα:Titr:Pt:Ορός:Ημιποσοτική:Ανοσοφθορισμός
Synonyms: Pt SERO Titr Ανθρώπινος παράγοντας δέσμευσης ανάντη Ανοσοφθορισμός Αντίσωμα Ημιποσοτική Ορός
es-ESSpanish (Spain)factor de unión upstream humano Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:Inmunofluorescencia (IF)
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Factor de unión aguas arriba Ab humano:Título:Punto temporal:Suero:Cuantitativo:Inmunofluorescencia (IF)
fr-CAFrench (Canada)NOR-90, Ac:Titre:Temps ponctuel:Sérum:SemiQn:Immunofluorescence
fr-FRFrench (France)NOR-90 Ac:Titre:Ponctuel:Sérum:Semi-Quantitatif:Immunofluorescence
it-ITItalian (Italy)Fattore umano a monte legante Ab:Titr:Pt:Siero:SemiQn:IF
Synonyms: anticorpo hUBF Immunofluorescenza (IF) Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NLDutch (Netherlands)Humaan upstream binding factor As:titer:moment:serum:semikwantitatief:immunofluorescentie
Synonyms: antistof; antilichaam IF
pt-BRPortuguese (Brazil)NOR-9Título Ac:Título:Pt:Soro:Qn:Imunofluorescência
Synonyms: Nucleolus organizer regions; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; ACIF; FA; Fluorescent antibody; Immune fluorescence; Fluoresent; Immunoflour; Immunofluor; Immunofluorescence; IFA; Time Resolved Fluorescence; Anticomplement Immunofluorescence; TRF; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
zh-CNChinese (China)人上游结合因子 抗体:滴定度:时间点:血清:半定量型:免疫荧光法
Synonyms: Ab;自身抗体 IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 人上遊結合因子;人类上游结合因子;hUBF;Human upstream binding factor 因素 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 系数 结合性 结合性的 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

UnitSource
{titer}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=54004-7