Version 2.78

Part Descriptions

LP100021-7   Cells.CD3+CD8+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP14441-7   Cells.CD3+CD4+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP14441-7   Cells.CD3+CD4+
HIV infection decreases the number of CD4 T-cells, also called T4 helper cells, the ratio of CD4 to CD8 T-cells and the number of CD8+ T-cells. These counts are ordered frequently to guide decisions about anti-retroviral therapy. Laboratories usually report both percentage and absolute count. When you map CD4 and CD8 markers, be careful! Since at least 1997, CDC has required the detection of both CD3+ and CD4+ to identify T4 helper cells, because the CD3 marker is needed to identify T-cell . So, any tests that report T4 helper cells are really reporting cells that carry BOTH the CD3+ and the CD4+ markers. The measure name may be CD3+ CD4+ cells, CD4+ marker, T4 cells or even just CD4+ (a misnomer). Exactly analogous rules apply to CD8+. Measures that include only CD4 or only CD8 in their name are really measuring CD3+CD4+ cells or CD3+CD8+ cells, respectively and should be reported with the LOINC code that includes both of those markers. The panel named T cell subsets will usually contain both CD3 + CD4 and CD3 + CD8 counts. These names assume that one has already gated to lymphocytes only. Lymphocytes are identified by CD45 markers. So a CD45+CD3+CD4+ is a more complicated way to name CD3+C4+ cells and in the context of looking for CD4 helper T cells they are the same . The same applies to other flow cytometer measures that are looking only at lymphocytes (B-cells, NK cells, etc). Source: Regenstrief Help

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

Reference Information

Type Source Reference
Mapping Guidance Regenstrief Help Need CD3 as well as CD4 and CD3 as well as CD8 to accurately identify ratio of CD4 T cell to CD8 T cell. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Fully-Specified Name

Component
Cells.CD3+CD4+/Cells.CD3+CD8+
Property
NRto
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
CD3+CD4+ Cells/CD3+CD8+ Cells Bld
Display Name
CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells (Bld) [# ratio]
Consumer Name Alpha Get Info
CD3+CD4+ (T4 Helper) Cells/CD3+CD8+ (T8 Suppressor Cells) Cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
726

Member of these Panels

LOINC Long Common Name
49120-9 Immunodeficiency follow-up panel - Specimen by Flow cytometry (FC)
80721-4 Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
65759-3 T-cell subsets CD4 and CD8 panel - Blood

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: CD4/CD8-Ratio
de-DE German (Germany) Zellen.CD3+CD4+/Zellen.CD3+CD8+:Zahlenverhältnis:Zeitpunkt:Blut:Quantitativ:
es-ES Spanish (Spain) Células CD3+CD4+/Células CD3+CD8+:Relación de número:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cells.CD3 + CD4 + / Cells.CD3 + CD8 +:Proporción numérica:Punto temporal:Sangre:Cuantitativo:
et-EE Estonian (Estonia) Rakud.CD3+CD4+/rakud. CD3+CD8+:NRto:Pt:B:Qn:
Synonyms: Juhuslik Kvantitatiivne Veri
fr-CA French (Canada) Cellules.CD3+CD4+/Cellules.CD3+CD8+:Ratio de numérique:Temps ponctuel:Sang:Quantitatif:
fr-FR French (France) CD3+CD4+/CD3+CD8+:Nombre/Nombre:Ponctuel:Sang:Numérique:
fr-BE French (Belgium) Cellules.CD3+CD4+/Cellules.CD3+CD8+:Ratio de numérique:Temps ponctuel:Sang:Quantitatif:
Synonyms: Rapport.numérique
it-IT Italian (Italy) Cellule.CD3+CD4+/Cellule.CD3+CD8+:NRto:Pt:Sangue:Qn:
Synonyms: Cellule CD3 Cellule CD3+CD4+ Cellule CD3+CD8+ Cellule CD3+CD8+ (cellule soppressore T8) Cellule CD3-CD4+ Modelli di superficie cellulare Punto nel tempo (episodio) Rapporto numerico Sangue
nl-NL Dutch (Netherlands) cellen.CD3+CD4+/cellen.CD3+CD8+:aantalsverhouding:moment:bloed:kwantitatief:
pt-BR Portuguese (Brazil) Células.CD3+CD4+/Células CD3+CD8+:#N/A:Pt:SgTotal:Qn:
Synonyms: ; CD3+CD8+ Cells; CD3 Cells; Cell; Cellularity; Leu-4; Leu4; T3; Number ratio; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; Leu-2; T-8; Leu2; Suppressor T cells; T8; Tsuppressor; Leu-3; T-4; Leu3; W3/25; Helper T cells; Inducer T cells; T4; L3T4; CELL MARKERS
ru-RU Russian (Russian Federation) Клетки.CD3+CD4+/Клетки.CD3+CD8+:КолОтн:ТчкВрм:Кр:Колич:
Synonyms: CD3+CD4+ (T4 хэлперы) клетки CD3+CD8+ (T8 клетки-супрессоры) клетки Количественное отношение Количественный Кровь Точка во времени;Момент
tr-TR Turkish (Turkey) Hücreler.CD3+CD4+/Hücreler.CD3+CD8+:SayOr:Zmlı:Kan:Kant:
uk-UA Ukrainian (Ukraine) Клітини.CD3+CD4+/Клітини.CD3+CD8+:Чисельне Співвідношення:МоментЧасу:Кров:Кількісно:
Synonyms: Blood; CD3 Cells; CD3+CD4+ Cells; CD3+CD8+ Cells; CD3-CD4+; CD4+ T cells; CD8 T cells; Cell; CELL MARKERS; Cellularity; Helper T cells; Inducer T cells; L3T4; Leu2; Leu-2; Leu3; Leu-3; Leu4; Leu-4; Number ratio; Point in time; QNT; Quan; Quant; Quantitative; Random; Suppressor T cells; Suppressor/cytotoxic T cells; T3; T4; T-4; T4 helper/inducer cells; T8; T-8; T8 suppressor cells; Tsuppressor; W3/25; WB; Whole blood
zh-CN Chinese (China) 细胞.CD3+CD4+/细胞.CD3+CD8+:计数型比率:时间点:全血:定量型:
Synonyms: CD3+CD4+细胞 CD3+CD8+细胞 CD3-CD4+细胞 CD3细胞 L3T4 Leu2 Leu-2 Leu3 Leu-3 Leu4;Leu-4;T3 T4 T-4 T8 T-8 Tsuppressor W3/25 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 抑制性 T 细胞 抑制性 T-细胞 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=54218-3