Log In

Part Description

LP93517-8   Human epididymis protein 4
Human epididymis protein 4 (known as HE4, or as WAP four-disulfide core domain protein 2) is a protein that in humans is encoded by the WFDC2 gene and belongs to the family of whey acidic four-disulfide core (WFDC) proteins. HE4 is overexpressed in both ovarian and endometrial cancers and is an important biomarker that complements CA 125 in discriminating between benign and malignant pelvic masses, monitoring response to treatment, and detecting recurrences of both ovarian and endometrial cancer. The risk of ovarian malignancy algorithm (ROMA) includes CA 125, HE4, and menopausal status to distinguish benign from malignant adnexal masses. HE4 may augment the sensitivity of CA 125 for detecting early-stage ovarian cancer. PMID: 23909069 Source: Regenstrief LOINC, PMID: 23909069

Reference Information

TypeSourceReference
Fda 510KRegenstrief Help FDA_510k

LOINC Names Get Info

Fully-Specified Name
Human epididymis protein 4:SCnc:Pt:Ser/Plas:Qn:
Long Common Name
Human epididymis protein 4 [Moles/volume] in Serum or Plasma
Short Name
HE4 SerPl-sCnc
Display Name
Human epididymis protein 4 [Moles/Vol]
Consumer Name Alpha Get Info
Human epididymis protein 4, Blood

Part Model Get Info

  • Component
    Human epididymis protein 4
    LP93517-8
    • Analyte
      Human epididymis protein 4
      LP93517-8
      • Component Numerator
        Human epididymis protein 4
        LP93517-8
        • Component Numerator Core
          Human epididymis protein 4
          LP93517-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SCnc
    LP6860-3
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.73 (MIN)
Change Reason
System changed from serum to fit the updated procedures.
Order vs. Observation
Both
Common Test Rank Get Info
4718

Member of these Panels

LOINCLong Common Name
104551-7Ovarian malignancy (ROMA) panel - Serum or Plasma

Member of these Groups Get Info

LOINC GroupGroup Name
LG51042-6Human epididymis protein 4|Pt|Ser/Plas
LG22449-9Human epididymis protein 4|SCnc|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
ar-JOArabic (Jordan)بروتين البربخ البشري 4 في المصل أو البلازما ( بتقنية عدد المولات / الحجم )
cs-CZCzech (Czechia)Lidský epididymální protein 4 (HE4):Látková koncentrace:Časový bod:Sérum/plazma:Kvantitativní:
de-ATGerman (Austria)Synonyms: HE4
de-DEGerman (Germany)Humanes Epididymis-Protein 4:Stoffmengenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
el-GRGreek (Greece)Πρωτεΐνη ανθρώπινης επιδιδυμίδας 4:SCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: CHEM Pt Qn SCnc Ορός Ορός/Πλάσμα Πλάσμα Πρωτεΐνη Πρωτεΐνη ανθρώπινης επιδιδυμίδας 4
es-ESSpanish (Spain)Proteína 4 del epidídimo humano:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Proteína 4 del epidídimo humano:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
et-EEEstonian (Estonia)Kasvajaantigeen HE4:SCnc:Pt:S/P:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-FRFrench (France)Protéine HE4:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BEFrench (Belgium)Protéine 4. épididyne humain:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-CAFrench (Canada)Protéine 4 épididyme humaine:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-ITItalian (Italy)Epididimo umano, proteina 4:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Sostanza Plasma Proteina 4 dell''epididimo umano Punto nel tempo (episodio) Siero Siero o Plasma
nl-NLDutch (Netherlands)Humaan epididymis proteïne 4:mol/volume:moment:serum of plasma:kwantitatief:
pl-PLPolish (Poland)Podfrakcja 4 ludzkiego białka komórek nabłonkowych najądrza:stężenie molowe:punkt w czasie:surowica lub osocze:ilościowy:
Synonyms: Białko HE4
pt-BRPortuguese (Brazil)Proteína humana epidídimo 4:#N/A:Pt:Soro:Qn:
Synonyms: ; Prot; PR; HE4; Substance concentration; Level; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Chemistry
ru-RURussian (Russian Federation)Человеческий придаток яичка протеин 4:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Белок Белок 4 эпидидимиса человека Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TRTurkish (Turkey)Human epididymis protein 4:SubKons:Zmlı:Ser/Plaz:Kant:
uk-UAUkrainian (Ukraine)Людський епідідімальний білок 4:Молярна Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: Chemistry; Endometrial cancer; Gyn; Gynecology; HE4; Level; OB; ObGyn; Obstetrics; Ovarian cancer; Pl; Plasma; Plsm; Point in time; PR; Prot; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; Substance concentration; Tumor marker; UniversalLabOrders; WAP four-disulfide core domain protein 2
zh-CNChinese (China)人附睾蛋白 4:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 人类附睾蛋白 4;HE4;Human epididymal protein 4;人附睾上皮分泌蛋白 4;人附睾分泌蛋白 4 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清或血浆

Example Units

UnitSource
pmol/LExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=55180-4