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Part Description

LP94227-3   Zygosity
Polymorphic DNA markers are used to determine if twins (triples, etc.) are monozygotic (identical) or dizygotic (fraternal). In some cases, labs may require DNA from the parents to ensure markers are informative and provide the most accurate results. Genotypes derived from the analysis of the markers are compared between the siblings (and parents). Any differences indicate dizygosity. If siblings share the same genotypes, they are considered identical.

Zygosity testing is performed for several reasons, including determining genetic risk for an individual whose sibling is affected with a genetic disorder for which a specific genetic test is uninformative or not available, assessing risks prenatally when one fetus of multiples is known to be affected by a specific disorder, performing organ or bone marrow transplantation compatibility testing, evaluating twin-twin transfusion syndrome during pregnancy, and for general familial or parental interest. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Zygosity:Prid:Pt:Bld/Tiss:Nom:Molgen
Long Common Name
Zygosity [Identifier] in Blood or Tissue by Molecular genetics method Nominal
Short Name
Zygosity Bld/T
Display Name
Zygosity Molgen Nom (Bld/Tiss)
Consumer Name Alpha Get Info
Zygosity, Blood or tissue specimen

Part Model Get Info

  • Component
    Zygosity
    LP94227-3
    • Analyte
      Zygosity
      LP94227-3
      • Component Numerator
        Zygosity
        LP94227-3
        • Component Numerator Core
          Zygosity
          LP94227-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Molgen
    LP6404-0

Example Answer List: LL2186-6

Source: Regenstrief LOINC
AnswerCodeScoreAnswer ID
Twin X and Twin Y are dizygotic (fraternal)LA18941-7
Twin X and Twin Y are monozygotic (identical)LA18940-9

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.70 (MAJ)
Change Reason
Release 2.70: SYSTEM: Updated System to the more general molecular genetics Specimen of Bld/Tiss since this test can be performed on various specimens, including buccal swabs and whole blood. The cells collected from the cheek swabs falls under the "Tiss" Specimen type in LOINC. The results (e.g. fraternal, identical) from either specimen types obtained from twins or multiples would be the same.; Previous Releases: Removed 'Twin' from Component since term was misleading. It could have been interpreted as zygosity testing on twins only, not other types of multiples (triplets, etc.).
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Zygozita:Přítomnost nebo identita:Časový bod:Krev/tkáň:Nominální:Molekulární genetika
el-GRGreek (Greece)Ζυγωτία:Prid:Pt:Αίμα/Ιστός:Nom:Μοριακή γενετική
Synonyms: MOLPATH Nom Prid Pt Αίμα Αίμα/Ιστός Ζυγωτία Ιστός Μοριακή γενετική
es-ESSpanish (Spain)Zigosidad de gemelos:Presencia o identidad:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MXSpanish (Mexico)Cigosidad:Presencia o identidad:Punto temporal:Bucal:Nominal:Genética molecular
fr-FRFrench (France)Zygosité:Identification:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-ITItalian (Italy)Gemelli, zigosità:Prid:Pt:Sangue/Tess:Nom:Molgen
Synonyms: DNA di zigosità di gemelli Genetica molecolare Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)zygositeit:identificator:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: molgen
pl-PLPolish (Poland)Zygotyczność:obecność lub identyfikacja:punkt w czasie:krew lub tkanka:skala nominalna:genetyka molekularna
Synonyms: diagnostyka molekularna wynik kategorialny
pt-BRPortuguese (Brazil)Gêmeo zigoto:Ident:Pt:Bocal:Nom:Genética molecular
Synonyms: ; Twin zygosity DNA; Identity or presence; Point in time; Random; Nominal; PCR; Molecular genetics; Molecular pathology
ru-RURussian (Russian Federation)Зиготность:ПрИд:ТчкВрм:Кр/Тк:Ном:МолГен
Synonyms: Зиготность ДНК Кровь Кровь или Ткань Номинальный;Именной Присутствие или Идентификация Ткань и мазки Точка во времени;Момент
tr-TRTurkish (Turkey)ZigositeDNA:MevcKimlik:Zmlı:Kan/Dk:Snf:Molgen
zh-CNChinese (China)接合性:存在与否或特征标识:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 卵型;合子型 存在;存在与否;特征标识;身份;身份标识 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=55198-6