LOINC
Version 2.73

55380-0West Nile virus Ab [Titer] in Serum by Hemagglutination inhibitionActive

Part Descriptions

LP28423-9   West Nile virus
The West Nile Virus (WNV) is an arbovirus that was first identified in the West Nile District of Uganda in 1937. In the fall of 1999, the National Veterinary Services Laboratory (NVLS) isolated WNV in a dead crow in New York City.(http://www.who.int/mediacentre/factsheets/fs354/en/) Over the following ten years, WNV spread throughout the United States, Canada, Mexico and the Carribbean. WNV is usually transmitted through the bite of the Culex mosquito, but can also be spread in blood transfusions, organ transplants, breast milk, intrauterine exposure and laboratory-acquired infections. Birds are the preferred host of WNV, and the American robin is an important amplifier host since it develops enough virus in its serum to infect feeding mosquitoes. Though most infections with WNV are subclinical for humans, between 2005 and 2009 there were 12,975 people infected with WNV, of which 35% had severe cases of neuroinvasive disease and 496 people died. For individuals who are 70 years of age or older, infection with WNV has a 15-29% fatality rate. For infants and immunocompromised patients infected with WNV, the fatality rate is even higher. Diagnosis of WNV is based on clinical symptoms and antibody titers. The IgM antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) is the key method used to diagnosis WNV in clinical settings. Antibody titers to WNV NS5 are detectable long-term in vivo and can be used to distinguish past infection with WNV from current infection. RNA is usually undetectable in serum after 13.2 days, but on rare occasions, has been found in serum beyond 40 days. Treatment of infection with WNV is mostly supportive. There are no FDA-approved drugs or vaccines available.[PMID:12089283][PMID:23034323] Source: Regenstrief LOINC

LP6304-2   HAI
The hemagglutination-inhibition assay (HAI) can be used to identify subtypes of hemagglutinin producing viruses, such as Influenza. HAI can also be used to identify the subtype-specificity of antibodies against the virus. Normally, Influenza's hemagglutinin glycoprotein binds to receptors on the surface of red blood cells, causing them to agglutinate. If antibodies specific to the virus are present in the patient sample, they will bind to the virus, which prevents the virus from binding to the red blood cells and therefore prevents agglutination. To determine which subtype of virus is present, a viral isolate is tested against a series of antibodies with known subtype specificities. Whichever antibody inhibits red cell agglutination identifies the viral subtype. Similarly, antibody specificity is identified by testing the patient sample against known virus subtypes. [PMID:24899416] Source: Regenstrief LOINC

Fully-Specified Name

Component
West Nile virus Ab
Property
Titr
Time
Pt
System
Ser
Scale
Qn
Method
HAI

Additional Names

Short Name
WNV Ab Titr Ser HAI
Display Name
West Nile virus Ab HAI (S) [Titer]
Consumer Name Alpha
West Nile virus antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.32
Order vs. Observation
Both

Member of these Groups

LG32768-0 West Nile virus

Language Variants Get Info

zh-CNChinese (China)
西尼罗河病毒 抗体:滴定度:时间点:血清:定量型:红细胞凝集抑制试验法
nl-NLDutch (Netherlands)
West-Nijlvirus As:titer:moment:serum:kwantitatief:hemagglutinatieremming
fr-BEFrench (Belgium)
Virus du Nil occidental Ac:Titre:Temps ponctuel:Sérum:Quantitatif:Inhibition de l'hémagglutination
fr-CAFrench (Canada)
Virus du Nil occidental , Ac:Titre:Temps ponctuel:Sérum:Quantitatif:Inhibition de l'hémagglutination
fr-FRFrench (France)
West Nile virus Ac:Titre:Ponctuel:Sérum:Numérique:Hémagglutination indirecte
it-ITItalian (Italy)
Nilo occidentale, virus Ab:Titr:Pt:Siero:Qn:HAI
pt-BRPortuguese (Brazil)
Vírus do Nilo Ocidental Ac:#N/A:Pt:Soro:Qn:Inibição da hemaglutinação
es-MXSpanish (Mexico)
Ab virus del Nilo Occidental:Título:Punto temporal:Suero:Cuantitativo:Inhibición de la hemaglutinación
es-ESSpanish (Spain)
Virus Nilo Occidental Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Qn:Inhibición de la Hemaglutinación
tr-TRTurkish (Turkey)
Batı Nil virüsü Ab:Titr:Zmlı:Ser:Kant:HAI

Example Units

Unit Source
{titer} Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=55380-0