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Part Description

LP16758-2   SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

LOINC Names Get Info

Fully-Specified Name
SCL-70 extractable nuclear Ab:PrThr:Pt:Ser:Ord:IB
Long Common Name
SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
Short Name
ENA Scl70 Ab Ser Ql IB
Display Name
SCL-70 extractable nuclear Ab IB Ql (S)
Consumer Name Alpha Get Info
SCL-70 extractable nuclear antibody, Blood

Part Model Get Info

  • Component
    SCL-70 extractable nuclear Ab
    LP39721-3
    • Analyte
      SCL-70 extractable nuclear Ab
      LP39721-3
      • Component Numerator
        SCL-70 extractable nuclear Ab
        LP39721-3
        • Component Numerator Core
          SCL-70 extractable nuclear
          LP16758-2
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    IB
    LP6320-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.58 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG5141-9SCL-70 extractable nuclear Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Antinukleární protilátky SCL-70 extrahovatelné:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Imunoblot
de-ATGerman (Austria)Synonyms: Scl-70 AK ql. IB
de-DEGerman (Germany)SCL-70 extrahierbarer nukleärer Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoblot
Synonyms: Scl-70
el-GRGreek (Greece)Εκχυλίσιμα πυρηνικά SCL-70 Αντίσωμα:PrThr:Pt:Ορός:Ord:IB
Synonyms: IB Ord PrThr Pt SERO Αντίσωμα Εκχυλίσιμα πυρηνικά Εκχυλίσιμα πυρηνικά SCL-70 Ορός Πυρηνικό
es-ESSpanish (Spain)Antígeno nuclear extraíble SCL-70 Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunoblot (IB)
es-MXSpanish (Mexico)Ab nuclear extraíble SCL-70:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunotransferencia
fr-CAFrench (Canada)SCL-70 nucléaire soluble, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoblot
fr-FRFrench (France)SCL-70 Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoblot
fr-BEFrench (Belgium)SCL-70 nucléaire soluble Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunoblot
Synonyms: Anticorps
it-ITItalian (Italy)Nucleare estraibile SCL-70 Ab:PrThr:Pt:Siero:Ord:IB
Synonyms: anticorpo ENA Immunoblot (IB) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)SCL-70 extraheerbare nucleaire As:aanwezigheid:moment:serum:ordinaal:immunoblotting
Synonyms: antistof; antilichaam IB
pl-PLPolish (Poland)SCL-70 rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:surowica:uporządkowany:immunoblotting
Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
pt-BRPortuguese (Brazil)SCL-70 Ac:#N/A:Pt:Soro:Ord:Imunoblot
Synonyms: ; ENA Scl70; Scleroderma Ac; ANA; ANF; NA; Antinuclear antibody; Nuc; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Western blot; WB; Immune blot; Immunobl; Blt; WBLOT; West blt; West blot; RIBA; Immunoblot; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RURussian (Russian Federation)SCL-70 экстрагируемый ядерный Ат:PrThr:ТчкВрм:Сыв:Пор:ИБ
Synonyms: Антитело Иммуноблот (ИБ) Порядковый Сыворотка Точка во времени;Момент
tr-TRTurkish (Turkey)SCL-70 özütlenebilir nükleer Ab:MevcEşik:Zmlı:Ser:Srl:IB
Synonyms: Ak Çekirdek Mevcut
zh-CNChinese (China)SCL-70 可提取性核 抗体:存在情况或阈值:时间点:血清:序数型:免疫印迹法
Synonyms: Ab;自身抗体 ANA ENA Ab ENA SCL-70 Ab ENA SCL-70 抗体 ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ag Ab SCL-70 可提取性核抗原抗体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫印迹;西部印迹法;Immunoblot;immunoblotting;IB 可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 抗体 可提取性核抗原之抗体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 时刻;随机;随意;瞬间 核;胞核 皮硬化症 硬皮病 硬皮病（Scleroderma，SCL） 硬皮症 细胞核 Ab 胞核 Ab 胞核抗体 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=56693-5