LOINC
Version 2.73

56741-2Ganglioside GQ1b IgG Ab [Presence] in Serum by ImmunoblotActive

Part Descriptions

LP28754-7   Ganglioside GQ1b
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID:21214559] Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC, PMID: 2121455

Fully-Specified Name

Component
Ganglioside GQ1b Ab.IgG
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IB

Additional Names

Short Name
GQ1b Gangl IgG Ser Ql IB
Display Name
Ganglioside GQ1b IgG IB Ql (S)
Consumer Name Alpha
Ganglioside GQ1b IgG antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.58
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
82454-0 Ganglioside Ab panel - Serum by Immunoblot

Member of these Groups

LG5152-6 Ganglioside GQ1b Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
神经节苷脂 GQ1b 抗体.IgG:存在情况或阈值:时间点:血清:序数型:免疫印迹法
nl-NLDutch (Netherlands)
ganglioside GQ1b As.IgG:aanwezigheid:moment:serum:ordinaal:immunoblotting
et-EEEstonian (Estonia)
Gangliosiid GQ1b antikehad.IgG:PrThr:Pt:S:Ord:IB
fr-BEFrench (Belgium)
Ganglioside GQ1b Anticorps. IgG:PrThr:Temps ponctuel:Sérum:Ordinal:Immunoblot
fr-CAFrench (Canada)
Ganglioside GQ1b , IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoblot
fr-FRFrench (France)
Ganglioside GQ1b anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoblot
it-ITItalian (Italy)
Ganglioside GQ1b Ab.IgG:PrThr:Pt:Siero:Ord:IB
pt-BRPortuguese (Brazil)
Gangliosideo GQ1b Ac.IgG:#N/A:Pt:Soro:Ord:Imunoblot
ru-RURussian (Russian Federation)
Ганглиозид GQ1b Ат.IgG:PrThr:ТчкВрм:Сыв:Пор:ИБ
es-MXSpanish (Mexico)
Gangliósido GQ1b Ab.IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunotransferencia
es-ESSpanish (Spain)
Gangliósido GQ1b IgG:PrThr:Punto temporal:Suero:Ord:Inmunoblot (IB)
tr-TRTurkish (Turkey)
Gangliozid GQ1b Ab.IgG:MevcEşik:Zmlı:Ser:Srl:IB

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=56741-2