57775-9
Valproate.free and Valproate panel - Serum or Plasma
Active
4087-3 Valproate Free [Mass/volume] in Serum or Plasma
Part Descriptions
LP207910-3 free DRUG/TOX
The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug PMID: 6636249. For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity.
Source: Regenstrief LOINC
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Valproate.free
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- Order_Obs: changed from 'observation' to 'both' to reflect that the LOINC code can also be used as an order code.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 1810
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 54037-7 | HEDIS 2009 panel |
| 57820-3 | HEDIS 2010 panel |
| 60442-1 | HEDIS 2011 panel |
| 67767-4 | HEDIS 2012 panel |
| 72199-3 | HEDIS 2013 panel |
| 74234-6 | HEDIS 2014 Value Sets |
| 57775-9 | Valproate.free and Valproate panel - Serum or Plasma |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG47174-4 | Valproate.free| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Valproát volný: |
| el-GR | Greek (Greece) | Βαλπροϊκό.ελεύθερο: Synonyms: DRUG/TOX MCnc Pt Qn Βαλπροϊκό οξύ Βαλπροϊκό.ελεύθερο Ορός Ορός/Πλάσμα Πλάσμα |
| es-AR | Spanish (Argentina) | valproato.libre: |
| es-ES | Spanish (Spain) | Valproico libre: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Valproato.libre: |
| et-EE | Estonian (Estonia) | Valproaat.vaba: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-CA | French (Canada) | Valproate.libre: |
| fr-FR | French (France) | Valproate libre: |
| fr-BE | French (Belgium) | Valproate.libre: |
| it-IT | Italian (Italy) | Valproato.libero: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma Valproato Libero |
| ko-KR | Korean (Korea, Republic Of) | 유리벨프로에이트: |
| nl-NL | Dutch (Netherlands) | valproaat.vrije: |
| pt-BR | Portuguese (Brazil) | Valproato.livre: Synonyms: Valproic acid; |
| ru-RU | Russian (Russian Federation) | Вальпроат.свободный: Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Valproat.serb: |
| zh-CN | Chinese (China) | 2-丙基戊酸.游离型: Synonyms: 2-丙基戊酸.游离; |
Example Units
| Unit | Source |
|---|---|
| ug/mL | Example UCUM Units |
| mcg/mL | REGENSTRIEF |
4086-5 Valproate [Mass/volume] in Serum or Plasma
Part Descriptions
LP16305-2 Valproate
Valproic acid is a compound used as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, juvenile myoclonic epilepsy and the seizures associated with Lennox-Gastaut syndrome. It is also used in treatment of myoclonus. In some countries, parenteral (administered intravenously) preparations of valproate are used also as second-line treatment of status epilepticus, alternatively to phenytoin. Related drugs include sodium valproate, used as an anticonvulsant, and a combined formulation, valproate semi-sodium, used as a mood stabilizer and anticonvulsant.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Valproate (Wikipedia)
LP16305-2 Valproate
Valproic acid is an anticonvulsant that is used alone or with other medication to treat certain types of seizures, mania in people with bipolar disorder, and to prevent migranes before they occur. it cannot be used to treat migranes once they begin.
Valproic acid can also be used for children with attention deficit hyperactivity disorder to treat outbursts of aggression or impaired intellectual functioning, developmental delays, and behavioral disturbances associated with Lennoz-Gastaut syndrome.[MedlinePlus Drug:a682412][NINDS:Disorders/All-Disorders/Lennox-Gastaut-Syndrome-Information-Page]
Source: Regenstrief LOINC
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Valproate
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 595
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 54037-7 | HEDIS 2009 panel |
| 57820-3 | HEDIS 2010 panel |
| 60442-1 | HEDIS 2011 panel |
| 67767-4 | HEDIS 2012 panel |
| 72199-3 | HEDIS 2013 panel |
| 74234-6 | HEDIS 2014 Value Sets |
| 55427-9 | Seizure disorder tracking panel |
| 57775-9 | Valproate.free and Valproate panel - Serum or Plasma |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG49789-7 | Valproate| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| ar-JO | Arabic (Jordan) | الفالبروات في المصل أو البلازما ( بتقنية الكتلة / الحجم ) |
| cs-CZ | Czech (Czechia) | Valproát: |
| de-AT | German (Austria) | Synonyms: Valproinsäure |
| de-DE | German (Germany) | Valproat: Synonyms: Valproinsäure |
| el-GR | Greek (Greece) | Βαλπροϊκό οξύ: Synonyms: DRUG/TOX MCnc Pt Qn Βαλπροϊκό οξύ Ορός Ορός/Πλάσμα Πλάσμα |
| es-AR | Spanish (Argentina) | valproato: |
| es-ES | Spanish (Spain) | Valproato: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Valproato: |
| et-EE | Estonian (Estonia) | Valproaat: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-CA | French (Canada) | Valproate: |
| fr-FR | French (France) | Valproate: |
| fr-BE | French (Belgium) | Valproate: |
| it-IT | Italian (Italy) | Valproato: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| ko-KR | Korean (Korea, Republic Of) | 벨프로에이트: |
| nl-NL | Dutch (Netherlands) | valproaat: |
| pt-BR | Portuguese (Brazil) | Valproato: Synonyms: Valproic acid; |
| ru-RU | Russian (Russian Federation) | Вальпроат: Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Valproat: |
| zh-CN | Chinese (China) | 2-丙基戊酸: Synonyms: 2-丙基戊酸钠; |
Example Units
| Unit | Source |
|---|---|
| ug/mL | Example UCUM Units |
| mcg/mL | REGENSTRIEF |