58416-9
MLH1 gene methylation [Presence] in Blood or Tissue by Molecular genetics method
Active
Part Descriptions
LP99240-1 MLH1 gene methylation
MLH1 gene methylation has been associated with many kinds of cancers with microsatellite instability
Source: Regenstrief LOINC
LP124510-1 gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.
More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation.
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Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- MLH1 gene methylation
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
- Molgen
Additional Names
- Short Name
- MLH1 gene methylation Bld/T Ql
- Display Name
- MLH1 gene methylation Molgen Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- MLH1 gene methylation, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.30
- Last Updated
- Version 2.73
- Change Reason
- Release 2.72: PROPERTY: Updated Property from Arb to align with similar terms; SYSTEM: Updated System from Tiss as this test can be done using blood or tissue specimens;
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 15582
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 85905-8 | Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Metilación del gen MLH1: |
| es-MX | Spanish (Mexico) | Metilación del gen MLH1: |
| fr-FR | French (France) | MLH1 gène méthylation: |
| it-IT | Italian (Italy) | MLH1, metilazione gene: Synonyms: Gene MLH1 Genetica molecolare Metilazione del gene MLH1 Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | MLH1 genmethylatie: Synonyms: MLH1 gen molgen |
| pt-BR | Portuguese (Brazil) | MLH1 gene metilação: Synonyms: MutL homolog 1, colon cancer, nonpolyposis type 2; |
| ru-RU | Russian (Russian Federation) | MLH1 ген метилирование: Synonyms: Кровь Кровь или Ткань Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | MLH1 geni metilation: Synonyms: Mevcut |
| zh-CN | Chinese (China) | MLH1 基因甲基化: Synonyms: COCA2; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=58416-9
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright