60279-7

IL28B gene associated variant rs12979860 [Presence] in Blood or Tissue by Molecular genetics method

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Part Descriptions

LP101192-5   IL28B gene associated variant rs12979860
The CC genotype is associated with a greater rate of sustained virological response than the TT or CT genotypes. Source: LOINC partner 1

LP101192-5   IL28B gene associated variant rs12979860
The Interleukin-28b (IL28B) gene is located on chromosome 19q13.13 and encodes interferon-lambda-3 (IFN-lambda-3). IL28B belongs to the gene family of interleukins and interleukin receptors. A single nucleotide polymorphism (g.39738787C>T, rs12979860) located near the IL28B gene is known to alter hepatitis C treatment-induced viral clearance. It is associated with an approximately twofold change in response to pegylated interferon-alpha (PEG-IFN-alpha) and ribavirin (RBV) treatments, both among patients of European ancestry (p = 1.06 x 10e-25) and African-Americans (p = 2.06 x 10e-3). Studies indicate that the virus was eradicated in ~80% of patients with wildtype alleles (C;C) compared to only about 25% of those with homozygous alleles (T;T). Patient's with heterozygous alleles (C;T) had an intermediate response. For HCV genotypes other than type 1 (HCV-1), the usefulness of predicting response to therapy based on this SNP is unknown. Source: Regenstrief LOINC, PMID: 19684573

Fully-Specified Name

Component

IL28B gene associated variant rs12979860

Property

PrThr

Time

Pt

System

Bld/Tiss

Scale

Ord

Method

Molgen

Additional Names

Short Name

IL28B rs12979860 Bld/T Ql

Display Name

IL28B gene associated variant rs12979860 Molgen Ql (Bld/Tiss)

Consumer Name Alpha Get Info

IL28B gene associated variant rs12979860, Blood or tissue specimen

Example Answer List: LL951-5

Basic Attributes

Class

MOLPATH.MUT

Type

Laboratory

First Released

Version 2.34

Last Updated

Version 2.73

Change Reason

Edited Component part from "Hepatitis C virus IL28B rs12979860 genotype" because the use of "hepatitis C virus" in the component name is misleading. The test reports a SNP variant near the IL28B gene, not in any hepatitis C gene. The results for this variant are used to predict the outcome of therapy for HCV.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Added "Tiss" to System "Bld" because this is a germline DNA test.

Order vs. Observation

Both

Common Test Rank Get Info

6552

Language Variants Get Info

Related Names

• Assoc
• Blood
• Chromosome 19q13 polymorphism
• Genetics
• HCV genotype 1
• Hep C
• Hepatitis C virus
• Heredity
• Heritable
• IFNL3
• IFN-lambda-3
• IL 28
• IL28B
• IL-28B
• IL28B Hepatitis C treatment predicting variant
• IL28B rs12979860
• IL28C
• Inherited
• interferon, lambda 3
• Interleukin 28b
• interleukin 28B (interferon, lambda 3
• Interleukin-28b
• Molecular genetics
• Molecular pathology
• MOLPATH
• MOLPATH.MUTATIONS
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• Tissue
• Tissue, unspecified
• WB
• Whole blood
• Whole blood or Tissue

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.