Version 2.78

Term Description

In newborn screening laboratories where dried blood spots (DBS) are the only available specimens, the test for T cell receptor excision circles (TREC) has been established as a reliable method in population-based pilot studies. TRECs are circular episomal DNA generated at the rearrangement of T cell antigen-receptor gene segments during maturation of T lymphocytes in the thymus. They are non-replicating byproducts that stay in the recent thymic emigrants in the peripheral blood. As such, they can serve as sensitive markers of T cell production in the newborn infant.
Source: Regenstrief LOINC

Part Description

LP111251-7   T-cell receptor excision circle
T cell receptor excision circles (TRECs) are formed as a byproduct of T cell receptor (TCR) generation in the thymus. Every T cell has a unique TCR, and formation of TCRs involves DNA rearrangement into different combinations of variable, diversity, and joining sequences. As these combinations are created, the remaining fragments of excised DNA form circular structures, or TRECs. The number of TRECs is proportional to T cell production, with low TREC numbers being an indicator of inadequate T cell production. In newborns, dried blood spot TREC analysis is used to screen for severe combined immunodeficiency as well as other disorders associated with low T cell counts, such as DiGeorge syndrome, trisomy 21, CHARGE syndrome, and congenital leukemia. PMID: 25937517 Source: Regenstrief LOINC

Fully-Specified Name

Component
T-cell receptor excision circle
Property
NCnc
Time
Pt
System
Bld.dot
Scale
Qn
Method
Probe.amp.tar

Additional Names

Short Name
TREC # DBS NAA+probe
Display Name
T-cell receptor excision circle NAA+probe (DBS) [#/Vol]
Consumer Name Alpha Get Info
T-cell receptor excision circle, Dried blood spot

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.34
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
11973

Member of these Panels

LOINC Long Common Name
104191-2 Guanidinoacetate methyltransferase (GAMT) deficiency newborn screening panel
54089-8 Newborn screening panel American Health Information Community (AHIC)
62333-0 Severe combined immunodeficiency (SCID) newborn screening panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Círculos de escisión del receptor de células T:Concentración de número:Punto temporal:gota de sangre (papel de filtro):Qn:Sonda con amplificación dirigida
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Círculo de escisión del receptor de células T:Concentración numérica:Punto temporal:DBS:Cuantitativo:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Récepteur cellules T cercle d'excision:Nombre/Volume:Ponctuel:Sang buvard:Numérique:PCR amplification de cible
it-IT Italian (Italy) Linfocita T, circolo di escissione recettore:NCnc:Pt:Sangue.su carta da filtro:Qn:Sonda.amp.tar
Synonyms: Chimica Circolo di escissione di recettore di linfocita T Concentrazione Numerica Linfocita T Punto nel tempo (episodio) Sangue Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Spot sangue secco
nl-NL Dutch (Netherlands) T-celreceptor excisiecirkel:aantal/volume:moment:gedroogde bloedspot:kwantitatief:probe-detectie
Synonyms: probe.amp.tar
ru-RU Russian (Russian Federation) T-клеточного рецептора исключения круг:КолОб:ТчкВрм:Кр.Сух.капл:Колич:Проба.усил.миш
Synonyms: ДНК проба;ДНК зонд Количественный Количество в объеме Кровь Кровь сухая капля Проба с мишени усилением Точка во времени;Момент
tr-TR Turkish (Turkey) T-hücresi reseptörü excision circle:SayKons:Zmlı:Kan.nokta:Kant:Prob.amf.hdf
zh-CN Chinese (China) T-细胞受体重排删除环:计数型浓度:时间点:全血.斑点:定量型:探针法.基因扩增.靶向
Synonyms: T 细胞;UCHL-1 T-細胞受體重排刪除環;T-細胞受體切除環;T-细胞受体重排删除环;T-细胞受体重排切割环;T-cell receptor excision circle;TREC;T cell receptor rearrangement excision circle 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 全血斑点(滤纸);滤纸;血液.斑点;血液斑点(滤纸) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 单位体积内的数量或计数;数量型浓度(单位体积);数量或计数型浓度(计数/体积);数量或计数型浓度(单位体积);计数型浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 扩增型 扩增性 数量型浓度 探针法.基因扩增.靶向 数量型浓度 探针法.扩增.靶向 数量或计数型浓度 探针法.扩增.靶向 时刻;随机;随意;瞬间 病毒负荷 病毒负荷量 病毒负载 病毒载量 病毒载量（Viral load） 经过扩增的 脱氧核糖核酸探针 血;血液 计数型浓度 探针法.基因扩增.靶向 计数型浓度 探针法.扩增.靶向

Example Units

Unit Source
{copies} Example UCUM Units

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=62320-7