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Part Descriptions

LP111482-8   TOP2A gene
DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP111482-8   TOP2A gene
The TOP2A gene (topoisomerase (DNA) II alpha 170kDa) [HGNC Gene ID:11989] is located on chromosome 17q21-q22. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010] [NCBI Gene ID:7153] Source: National Center for Biotechnology Information (NCBI) Gene

LOINC Names Get Info

Fully-Specified Name
TOP2A gene:Imp:Pt:Tiss:Nar:
Long Common Name
TOP2A gene [Interpretation] in Tissue Narrative
Short Name
TOP2A gene Tiss-Imp
Display Name
TOP2A gene Nar (Tiss) [Interp]
Consumer Name Alpha Get Info
Interpretation of TOP2A gene test result, Tissue

Part Model Get Info

  • Component
    TOP2A gene
    LP111482-8
    • Analyte
      TOP2A gene
      LP111482-8
      • Component Numerator
        TOP2A gene
        LP111482-8
        • Component Numerator Core
          TOP2A gene
          LP111482-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Nar
    LP7749-7
  • Method
    NULL
     

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.36
Last Updated
Version 2.36 (MIN)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen TOP2A:Interpretace:Časový bod:Tkáně a stěry:Narativní:
el-GRGreek (Greece)Γονίδιο TOP2A:Imp:Pt:Ιστός:Nar:
Synonyms: Imp MOLPATH Nar Pt Γονίδιο Γονίδιο TOP2A Ιστός
es-ESSpanish (Spain)Gen TOP2A:Impresión/interpretación del estudio:Punto temporal:Tejido:Narrativo:
es-MXSpanish (Mexico)Gen TOP2A:Impresión / interpretación del estudio:Punto temporal:Tejido y frotis:Narrativo:
fr-FRFrench (France)TOP2A gène:Interprétation:Ponctuel:Tissu:Résultat textuel:
it-ITItalian (Italy)TOP2A, gene:Imp:Pt:Tessuto:Nar:
Synonyms: Gene TOP2A Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Tessuto & Strisci
nl-NLDutch (Netherlands)TOP2A-gen:interpretatie:moment:weefsel en uitstrijkjes:tekstueel:
Synonyms: TOP2A gen
pl-PLPolish (Poland)TOP2A gen:ocena:punkt w czasie:tkanka i rozmazy:opisowy:
Synonyms: Gen TOP2A
ru-RURussian (Russian Federation)TOP2A ген:Впчт:ТчкВрм:Тк:Опис:
Synonyms: Впечатление/интерпретация исследования Описательный Ткань и мазки Точка во времени;Момент
tr-TRTurkish (Turkey)TOP2A geni:İzlnm:Zmlı:Doku:Öykü:
zh-CNChinese (China)TOP2A 基因:印象:时间点:组织与涂片:叙述型:
Synonyms: TOP2;TP2A;DNA gyrase;DNA topoisomerase (ATP-hydrolyzing);DNA topoisomerase 2-alpha;DNA topoisomerase II, 170 kD;DNA topoisomerase II, alpha isozyme;DNA 促旋酶;DNA 旋转酶;DNA 拓扑异构酶 (ATP-水解);DNA 拓扑异构酶 2-alpha;DNA 拓扑异构酶 II, 170 kD;DNA 拓扑异构酶 II, alpha 同工酶 分子病理学;分子病理学试验 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=63069-9