63254-7
Ganglioside GQ1b IgG Ab [Presence] in Serum by Immunoassay
Active
Part Descriptions
LP28754-7 Ganglioside GQ1b
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559
Source: Regenstrief LOINC,
PMID: 2121455
LP222219-0 Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified.
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- Ganglioside GQ1b Ab.IgG:
PrThr: Pt: Ser: Ord: IA - Long Common Name
- Ganglioside GQ1b IgG Ab [Presence] in Serum by Immunoassay
- Short Name
- GQ1b Gangl IgG Ser Ql IA
- Display Name
- Ganglioside GQ1b IgG IA Ql (S)
- Consumer Name Alpha Get Info
- Ganglioside GQ1b IgG antibody, Blood
Part Model Get Info
- Component
- Ganglioside GQ1b Ab.IgG
LP65734-3
- Analyte
- Ganglioside GQ1b Ab.IgG
LP65734-3
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- PrThr
LP217195-9
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- Ser
LP7567-3
- System Core
- Ser
LP7567-3
- Super System
- NULL
- Scale
- Ord
LP7751-3
- Method
- IA
LP217197-5
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.36
- Last Updated
- Version 2.56 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82455-7 | Ganglioside Ab panel - Serum |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG5152-6 | Ganglioside GQ1b Ab.IgG| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Gangliosid GQ1b IgG: |
| el-GR | Greek (Greece) | Γαγγλιοσίδη GQ1b Αντισώματα IgG: Synonyms: IA Ord PrThr Pt SERO Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Γαγγλιοσίδη Γαγγλιοσίδη GQ1b Ορός |
| es-ES | Spanish (Spain) | Gangliósido GQ1b IgG: |
| es-MX | Spanish (Mexico) | Gangliósido GQ1b Ab.IgG: |
| et-EE | Estonian (Estonia) | Gangliosiid GQ1b antikehad.IgG: Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Seerum |
| fr-CA | French (Canada) | Ganglioside GQ1b, IgG: |
| fr-FR | French (France) | Ganglioside GQ1b Ac IgG: |
| fr-BE | French (Belgium) | Ganglioside GQ1b Anticorps. IgG: Synonyms: Anticorps |
| it-IT | Italian (Italy) | Ganglioside GQ1b Ab.IgG: Synonyms: anticorpi IgG anticorpo Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | ganglioside GQ1b As.IgG: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Gangliozyd GQ1b Ab.IgG: Synonyms: IgG Przeciwciała do gangliozydu GQ1b przeciwciała IgG Przeciwciała IgG do gangliozydu GQ1b |
| ru-RU | Russian (Russian Federation) | Ганглиозид GQ1b Ат.IgG: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | Gangliozid GQ1b Ab.IgG: Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay Mevcut |
| zh-CN | Chinese (China) | 神经节苷脂 GQ1b 抗体.IgG: Synonyms: Ab.IgG; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://