63300-8
Nucleosome Ab [Presence] in Serum by Immunoassay
Active
Part Description
LP31804-5 Nucleosome
The nucleosome is the structural unit of chromatin and consists of a segment of dsDNA coiled around a histone core. Anti-chromatin autoantibodies, such as those found in patients with systemic lupus erythematosus (SLE) fall in to two categories: those directed against individual components of chromatin, such as DNA and histone, and those directed against the intact nucleosome. Traditionally anti-dsDNA antibodies have been among the ones used for diagnosis and monitoring of SLE, however, studies have shown that for some patients, the nucleosome is the primary antigen in SLE, and anti-nucleosome antibodies may provide a better reflection of disease activity. A subset of patients who are positive for anti-nucleosome antibodies but negative for anti-dsDNA antibodies may have a milder course of SLE that does not involve the kidneys. PMID: 25193804
Source: Regenstrief LOINC, PMID: 25193804
Fully-Specified Name
- Component
- Nucleosome Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IA
Additional Names
- Short Name
- Nucleosome Ab Ser Ql IA
- Display Name
- Nucleosome Ab IA Ql (S)
- Consumer Name Alpha Get Info
- Nucleosome antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.36
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG21386-4 | Nucleosome Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Nucleosoma Anticuerpos: |
| es-MX | Spanish (Mexico) | Ab nucleosoma: |
| et-EE | Estonian (Estonia) | Nukleosoom antikehad: Synonyms: Järgarvuline Juhuslik Seerum |
| fr-CA | French (Canada) | Nucléosome , Ac: |
| fr-FR | French (France) | Nucléosomes anticorps: |
| fr-BE | French (Belgium) | Nucléosome Ac: Synonyms: Anticorps |
| it-IT | Italian (Italy) | Nucleosoma Ab: Synonyms: anticorpo Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | nucleosoom As: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Nukleosom Ab: Synonyms: Przeciwciała do nukleosomów |
| ru-RU | Russian (Russian Federation) | Нуклеосома Ат: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | Nükleozom Ab: Synonyms: Ak İmmünölçüm, immünoassay Mevcut |
| zh-CN | Chinese (China) | 核小体 抗体: Synonyms: Ab; |
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