63338-8

SCL-70 extractable nuclear Ab [Titer] in Serum by Immunoassay

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Part Description

LP16758-2 SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC , PMID: 11229469

Fully-Specified Name

Component: SCL-70 extractable nuclear Ab
Property: Titr
Time: Pt
System: Ser
Scale: SemiQn
Method: IA

Additional Names

Long Common Name: SCL-70 extractable nuclear Ab [Titer] in Serum by Immunoassay
Short Name: ENA Scl70 Ab Titr Ser IA
Display Name: SCL-70 extractable nuclear Ab IA (S) [Titer]
Consumer Name Alpha Get Info: SCL-70 extractable nuclear antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.36
Last Updated: Version 2.75 (MAJ)
Change Reason: The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG13182-7	SCL-70 extractable nuclear Ab\|Titr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	Εκχυλίσιμα πυρηνικά SCL-70 Αντίσωμα:Titr:Pt:Ορός:Ημιποσοτική:IA Synonyms: Titr Εκχυλίσιμα πυρηνικά Εκχυλίσιμα πυρηνικά SCL-70 Πυρηνικό
es-ES	Spanish (Spain)	Antígeno nuclear extraíble SCL-70 Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:IA Synonyms: Semicuantitativo
es-MX	Spanish (Mexico)	Ab nuclear extraíble SCL-70:Título:Punto temporal:Suero:Cuantitativo:Inmunoensayo
fr-CA	French (Canada)	SCL-70 nucléaire soluble, Ac:Titre:Temps ponctuel:Sérum:SemiQn:IA
fr-FR	French (France)	SCL-70 anticorps:Titre:Ponctuel:Sérum:Semi-Quantitatif:Immunoanalyse
it-IT	Italian (Italy)	Nucleare estraibile SCL-70 Ab:Titr:Pt:Siero:SemiQn:IA Synonyms: anticorpo ENA Immunoassay Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NL	Dutch (Netherlands)	SCL-70 extraheerbare nucleaire As:titer:moment:serum:semikwantitatief:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	SCL-70 rozpuszczalny jądrowy Ab:miano:punkt w czasie:surowica:półilościowy:metoda immunologiczna Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
zh-CN	Chinese (China)	SCL-70 可提取性核抗体:滴定度:时间点:血清:半定量型:免疫测定法 Synonyms: Ab;自身抗体 ANA ENA Ab ENA SCL-70 Ab ENA SCL-70 抗体 ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ag Ab SCL-70 可提取性核抗原抗体免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 抗体可提取性核抗原之抗体抗 ENA 抗可提取性核 Ag 抗可提取性核抗原抗核 Ab 抗核抗体抗核抗体（Antinuclear antibody，ANA）效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数时刻;随机;随意;瞬间核;胞核皮硬化症硬皮病硬皮病（Scleroderma，SCL）硬皮症细胞核 Ab 胞核 Ab 胞核抗体血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
{titer}	Example UCUM Units

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Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.