Version 2.77

Part Description

LP16758-2   SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

Fully-Specified Name

Component
SCL-70 extractable nuclear Ab
Property
Titr
Time
Pt
System
Ser
Scale
SemiQn
Method
IA

Additional Names

Short Name
ENA Scl70 Ab Titr Ser IA
Display Name
SCL-70 extractable nuclear Ab IA (S) [Titer]
Consumer Name Alpha Get Info
SCL-70 extractable nuclear antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.36
Last Updated
Version 2.75
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG13182-7 SCL-70 extractable nuclear Ab|Titr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Antígeno nuclear extraíble SCL-70 Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:IA
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Ab nuclear extraíble SCL-70:Título:Punto temporal:Suero:Cuantitativo:Inmunoensayo
fr-CA French (Canada) SCL-70 nucléaire soluble , Ac:Titre:Temps ponctuel:Sérum:SemiQn:IA
fr-FR French (France) SCL-70 anticorps:Titre:Ponctuel:Sérum:Numérique:Immunoanalyse
it-IT Italian (Italy) Nucleare estraibile SCL-70 Ab:Titr:Pt:Siero:SemiQn:IA
Synonyms: anticorpo ENA Immunoassay Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NL Dutch (Netherlands) SCL-70 extraheerbare nucleaire As:titer:moment:serum:semikwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
pl-PL Polish (Poland) SCL-70 rozpuszczalny jądrowy Ab:miano:punkt w czasie:surowica:półilościowy:metoda immunologiczna
Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
zh-CN Chinese (China) SCL-70 可提取性核 抗体:滴定度:时间点:血清:半定量型:免疫测定法
Synonyms: Ab;自身抗体 ANA ENA Ab ENA SCL-70 Ab ENA SCL-70 抗体 ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ag Ab SCL-70 可提取性核抗原抗体 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 抗体 可提取性核抗原之抗体 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 核;胞核 皮硬化症 硬皮病 硬皮病（Scleroderma，SCL） 硬皮症 细胞核 Ab 胞核 Ab 胞核抗体 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=63338-8