Version 2.80

Part Description

LP113695-3   Carbapenem resistance genes
Carbapenems are stable to AmpC β-lactamases and extended-spectrum-β-lactamases. Carbapenemases are a diverse group of b-lactamases that are active not only against the oxyimino-cephalosporins and cephamycins but also against the carbapenems. Aztreonam is stable to the metallo-β-lactamases but many IMP and VIM producers are resistant, owing to other mechanisms. Carbapenemases were formerly believed to derive only from classes A, B, and D, but a class C carbapenemase has been described.

IMP-type carbapenemases (one of the metallo-β-lactamases)(class B): Plasmid-mediated IMP-type carbapenemases, 17 varieties of which are currently known, found in enteric Gram-negative organisms, Pseudomonas and Acinetobacter species.

VIM (Verona integron-encoded metallo-β-lactamase): A second growing family of carbapenemases, the VIM family, VIM enzymes occur mostly in P. aeruginosa, also P. putidaand, very rarely, Enterobacteriaceae.

Both IMP and VIM hydrolyse all β-lactams except monobactams, and evade all β-lactam inhibitors.

OXA (oxacillinase) group of β-lactamases (Class D): The OXA group of β-lactamases occur mainly in Acinetobacter species and are divided into two clusters. OXA carbapenemases hydrolyse carbapenems very slowly in vitro, and the high MICs seen for some Acinetobacter hosts (>64 mg/L) may reflect secondary mechanisms. They are sometimes augmented in clinical isolates by additional resistance mechanisms, such as impermeability or efflux. OXA carbapenemases also tend to have a reduced hydrolytic efficiency towards penicillins and cephalosporins.

KPC (K. pneumoniae carbapenemase) (Class A): A few class A enzymes, most noted the plasmid-mediated KPC enzymes, are effective carbapenemases as well. Ten variants, KPC-2 through KPC-11 are known, and they are distinguished by one or two amino-acid substitutions

The class A Klebsiella pneumoniae carbapenemase (KPC) is currently the most common carbapenemase.

CMY (Class C): The first class C carbapenemase was described in 2006 and was isolated from a virulent strain of Enterobacter aerogenes. It is carried on a plasmid, pYMG-1, and is therefore transmissible to other bacterial strains. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Wikipedia

Fully-Specified Name

Component
Carbapenem resistance genes
Property
Prid
Time
Pt
System
Isolate
Scale
Nom
Method
Probe.amp.tar

Additional Names

Long Common Name
Carbapenem resistance genes [Identifier] by NAA with probe detection
Short Name
CPR genes Islt NAA+probe
Display Name
Carbapenem resistance genes NAA+probe Nom (Isol)
Consumer Name Alpha Get Info
Carbapenemresistance genes

Example Answer List: LL1061-2

Source: Hong Kong Hospital Authority
Answer Code Score Answer ID
Class A gene detected (KPC) LA14134-3
Class B gene detected (IMP) LA14135-0
Class A gene not detected (KPC, IMP, SME) LA14136-8

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.36
Last Updated
Version 2.66 (MIN)
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Carbapenem Resistenz Gene
de-DE German (Germany) Carbapenem-Resistenzgene:Nachweis oder Identität:Zeitpunkt:Isolat:Nominal:Zielfragmentamplifikation mit Sondendetektion
el-GR Greek (Greece) Γονίδια ανθεκτικότητας στη καρβαπενέμη:Prid:Pt:Απομονωμένο στέλεχος:Nom:Ανιχνευτής.ενίσχυση.στόχου
Synonyms: Prid Γονίδια ανθεκτικότητας στη καρβαπενέμη Καρβαπενέμη
es-ES Spanish (Spain) Genes de resistencia a carbapenamos:Presencia o identidad:Punto temporal:Aislado:Nom:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Genes de resistencia a carbapenémicos:Presencia o identidad:Punto temporal:Aislado:Nominal:Amplificación de ácidos nucleicos con detección de sonda
fr-CA French (Canada) Gène de résistance à Carbapénème:Présence ou identité:Temps ponctuel:Isolat:Nominal:Sonde avec amplification de la cible
fr-FR French (France) Gènes de résistance aux carbapénèmases:Identification:Ponctuel:Isolat:Résultat nominal:PCR amplification de cible
fr-BE French (Belgium) Gène de résistance à Carbapénémase:Présence ou identité:Temps ponctuel:Isolat:Nominal:Sonde avec amplification de la cible
it-IT Italian (Italy) Geni carbapenem resistenti:Prid:Pt:Isolato:Nom:Sonda.amp.tar
Synonyms: Geni carbapenem resistenti Presenza o Identità Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) carbapenemresistentie-genen:identificator:moment:isolaat:nominaal:probe-detectie
Synonyms: probe.amp.tar
ru-RU Russian (Russian Federation) Карбапенемаза резистентность гены:ПрИд:ТчкВрм:Изолят:Ном:Проба.усил.миш
Synonyms: ДНК проба;ДНК зонд Номинальный;Именной Присутствие или Идентификация Проба с мишени усилением Точка во времени;Момент
tr-TR Turkish (Turkey) Karbapenemaz direnç genleri:MevcKimlik:Zmlı:İzolat:Snf:Prob.amf.hdf
zh-CN Chinese (China) 碳青霉烯类耐药基因:存在与否或特征标识:时间点:分离株:名义型:探针法.基因扩增.靶向
Synonyms: 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 分子病理学 - 基因类 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 基因 存在;存在与否;特征标识;身份;身份标识 扩增型 扩增性 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 电阻 碳青霉烯类（碳青霉烯类抗生素、碳青霉烯）耐药基因;碳青霉烯酶（碳青黴烯酶、碳青霉烯水解酶）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型）基因;碳青霉烯酶耐药基因类;碳青霉烯酶耐药基因 碳青霉烯类;碳青霉烯类抗生素 经过扩增的 耐性 脱氧核糖核酸探针 阻力

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