Version 2.73

63383-4Amphiphysin Ab [Presence] in Cerebral spinal fluid by ImmunoassayActive

Part Descriptions

LP30843-4   Amphiphysin
Amphiphysin is a protein associated with the cytoplasmic surface of synaptic vesicles and is encoded by the AMPH gene. Patients with stiff man syndrome and breast cancer can be positive with autoantibodies against the amphiphysin protein. Source: Regenstrief LOINC

LP37039-2   Amphiphysin Ab
Paraneoplastic syndromes (PNS) are diseases associated with remote effects of tumors, of which small-cell lung cancer (SCLC), ovarian cancer, breast cancer, thymoma, Hodgkin lymphoma, and testicular cancer are the most common. Stiff-person syndrome (SPS) is a rare neurological disorder characterized by stiffness of skeletal muscles with superimposed spasms, which can have an idiopathic or paraneoplastic component. First described in women with breast cancer and SPS, amphiphysin antibodies have been reported in patients with diverse paraneoplastic neurological disorders, and cancers. Amphiphysin antibodies are considered diagnosic for paraneoplastic neurologic syndromes and can direct the search for an occult tumor, recurrence of tumor, or second tumor. Source: ARUP Laboratories

LP37039-2   Amphiphysin Ab
Amphiphysin is a brain-enriched protein normally found only within the membrane of synaptic vesicles in neural tissue. Antibodies against amphiphysin (128kDa) are directed against the protein amphiphysin, and their presence plays an important diagnostic role in paraneoplastic syndromes (e.g. Lambert Eaton myasthenia syndrome, encephalomyelitis with rigidity, cerebellar syndrome, sensory neuronopathy, opsoclonus myoclonus ataxia, and Stiff-man syndrome). Paraneoplastic syndromes are autoantibody-mediated neurologic disorders most commonly associated with cancers of the lung, breast, ovaries or lymphatic system. Source: Regenstrief LOINC

Fully-Specified Name

Amphiphysin Ab

Additional Names

Short Name
Amphiphysin Ab CSF Ql IA
Display Name
Amphiphysin Ab IA Ql (CSF)
Consumer Name Alpha
Amphiphysin antibody, Spinal fluid

Basic Attributes

First Released
Version 2.36
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation

Member of these Groups

LG24036-2 Amphiphysin Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
双载蛋白 抗体:存在情况或阈值:时间点:脑脊液:序数型:免疫测定法
nl-NLDutch (Netherlands)
amfifysine As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:immunoassay
et-EEEstonian (Estonia)
Amfifüsiin antikehad:PrThr:Pt:CSF:Ord:IA
fr-BEFrench (Belgium)
Amphiphysine Ac:PrThr:Temps ponctuel:LCR:Ordinal:IA
fr-CAFrench (Canada)
Amphiphysine , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:IA
fr-FRFrench (France)
Amphiphysine anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Immunoanalyse
it-ITItalian (Italy)
Amfifisina Ab:PrThr:Pt:LCS:Ord:IA
ru-RURussian (Russian Federation)
Амфифизин Ат:PrThr:ТчкВрм:ЦСЖ:Пор:IA
es-MXSpanish (Mexico)
Amphiphysin Ab:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Inmunoensayo
es-ESSpanish (Spain)
Anfifisina Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:IA
tr-TRTurkish (Turkey)
Amfifizin Ab:MevcEşik:Zmlı:BOS:Srl:İA

LOINC FHIR® API Example - CodeSystem Request Get Info