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Part Description

LP134394-8   Circulating tumor cells.colon
Measures circulating epithelial cells that are assumed to be carcinoma cells. In the context of breast cancer, a count of greater than 5 circulating tumor calls per 7.5 mL predicts a significantly shorter survival than those with a less then 5. Test is based on immunologic stain for Epithelial Cell Adhesion Molecule (EpCAM) antigen which are manetically tagged to concentrate them, then stained with CD45+ Alophycocyan (CD45-APC), anti cytokeratin phycoerythrin 8, 18, and 19 (CK-PE) and PAPI to identify the nucleus. The goal is to find epithelium derived cells. EpCAM is not always present in tumor cells and it is not completely specific so CK-PE is needed to confirm epitelial, PAPI to verify that the object is a cell not depre and CD45 to detect and exclude white cells. In terms of markers, the cells of interest are those that EpCAM+ CK-PE+ PAPI+ (to be sure that they are cells) and CD45-APC negative (to exclude white cells. Counts from this manufacturer are reportes per 7.5ml.

At present only one product is approved by the FDA is ."CellSearch™ system (Veridex), and it is offered by all of the major laboratories. As of May 2011, It has only been approved for metastatic , breast, prostate and colorectal cancer. The test has not specificity for a particular cancer, but the cut off for deciding worse prognosis differs by organ. Other mechanisms for measuring Circulating Tumor cells , exist, most internally developed by laboratories and not fully automated. Another company has an experimental system that does not depend upon magnetically tagged EpCAM for a first pass cut- claims to be able to count more cells (30 cc of blood), and may be more sensitive. Source: Regenstrief Help

LOINC Names Get Info

Fully-Specified Name
Circulating tumor cells.colon:NCnc:Pt:Bld:Qn:
Long Common Name
Circulating tumor cells.colon [#/volume] in Blood
Short Name
CTC.colon # Bld
Display Name
Circulating tumor cells.colon (Bld) [#/Vol]
Consumer Name Alpha Get Info
Circulating tumor cells.colon, Blood

Part Model Get Info

  • Component
    Circulating tumor cells.colon
    LP134394-8
    • Analyte
      Circulating tumor cells.colon
      LP134394-8
      • Component Numerator
        Circulating tumor cells.colon
        LP134394-8
        • Component Numerator Core
          Circulating tumor cells.colon
          LP134394-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NCnc
    LP6836-3
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.38
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
12855

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Cirkulující nádorové buňky.tlusté střevo:Početní koncentrace:Časový bod:Krev:Kvantitativní:
el-GRGreek (Greece)Κυκλοφορούντα καρκινικά κύτταρα.ορθό:NCnc:Pt:Αίμα:Qn:
Synonyms: CHEM NCnc Pt Qn Αίμα Κόλον Κυκλοφορούντα καρκινικά κύτταρα Κυκλοφορούντα καρκινικά κύτταρα.ορθό Κύτταρα
es-ESSpanish (Spain)Células tumorales circulantes.colon:Concentración de número:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Células tumorales circulantes colon.:Concentración numérica:Punto temporal:Sangre:Cuantitativo:
fr-FRFrench (France)Cellules tumorales circulantes colon:Nombre/Volume:Ponctuel:Sang:Numérique:
it-ITItalian (Italy)Cellule tumorali circolanti.colon:NCnc:Pt:Sangue:Qn:
Synonyms: Chimica Concentrazione Numerica Punto nel tempo (episodio) Sangue Tumore circolante
nl-NLDutch (Netherlands)circulerende tumorcellen.colon:aantal/volume:moment:bloed:kwantitatief:
Synonyms: CTC
ru-RURussian (Russian Federation)Циркулирующие опухолевые клетки.ободочная кишка:КолОб:ТчкВрм:Кр:Колич:
Synonyms: Количественный Количество в объеме Кровь Точка во времени;Момент
tr-TRTurkish (Turkey)Dolaşımdaki tümör hücreleri.colon:SayKons:Zmlı:Kan:Kant:
zh-CNChinese (China)循环肿瘤细胞.结肠:计数型浓度:时间点:全血:定量型:
Synonyms: 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 单位体积内的数量或计数;数量型浓度(单位体积);数量或计数型浓度(计数/体积);数量或计数型浓度(单位体积);计数型浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 循环型 循环性 循环肿瘤细胞;Circulating tumor cell;CTC 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 结肠特异性;结肠的 血;血液

Example Units

UnitSource
{CTCs}/(7.5.mL)Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=68124-7