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Term Description

The International Scale (IS) was established in 2005 to standardize quantitative BCR-ABL1 measurements across tests and laboratories. (Hughes et al., Blood 2006). The IS is anchored to the baseline BCR-ABL1 expression level from the International Randomized Study of Interferon vs STI571 (IRIS) trial (100% IS) with a major molecular response (MMR) corresponding to 0.1% IS. (Hughes et al., N Engl J Med 2003). The IRIS trial and follow up studies have demonstrated that achieving MMR, or a 3-log reduction in BCR-ABL1 expression from the standardized baseline level, is a key clinical outcome. Percent ratios on the IS are obtained by multiplying the percent ratio (100 x BCR-ABL1/control gene) determined at local labs by a test-specific conversion factor (IS % ratio = local % ratio x conversion factor).
Source: LOINC partner 1

Part Description

LP136109-8   control transcript (International Scale)
The International Scale (IS) was established in 2005 to standardize quantitative BCR-ABL1 measurements across tests and laboratories. (Hughes et al., Blood 2006). The IS is anchored to the baseline BCR-ABL1 expression level from the International Randomized Study of Interferon vs STI571 (IRIS) trial (100% IS) with a major molecular response (MMR) corresponding to 0.1% IS. (Hughes et al., N Engl J Med 2003). The IRIS trial and follow up studies have demonstrated that achieving MMR, or a 3-log reduction in BCR-ABL1 expression from the standardized baseline level, is a key clinical outcome. Percent ratios on the IS are obtained by multiplying the percent ratio (100 x BCR-ABL1/control gene) determined at local labs by a test-specific conversion factor (IS % ratio = local % ratio x conversion factor). Source: LOINC partner 1

LOINC Names Get Info

Fully-Specified Name
t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale):NRto:Pt:Bld/Tiss:Qn:Molgen
Long Common Name
t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale) [# Ratio] in Blood or Tissue by Molecular genetics method
Short Name
t(ABL1,BCR)p210/Control (IS) Bld/T
Display Name
t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale) Molgen (Bld/Tiss) [# ratio]
Consumer Name Alpha Get Info
t(9;22)(q34.1;q11)(ABL1,BCR) B2a2+b3a2/control Transcript (International Scale), Blood or tissue specimen

Part Model Get Info

  • Component
    t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale)
    LP287180-6
    • Analyte
      t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale)
      LP287180-6
      • Component Numerator
        t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript
        LP229766-3
        • Component Numerator Core
          t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2
          LP150240-2
        • Component Numerator Core Suffix
          fusion transcript
          LP150217-0
      • Component Denominator
        control transcript (International Scale)
        LP136109-8
        • Component Denominator Core
          control transcript (International Scale)
          LP136109-8
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NRto
    LP6840-5
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Molgen
    LP6404-0

Basic Attributes

Class
MOLPATH.TRNLOC
Type
Laboratory
First Released
Version 2.38
Last Updated
Version 2.73 (MIN)
Change Reason
Release 2.69: PROPERTY: Property updated to be consistent with similar term 55147-3. RelRto was not correct as the ratio is comparing measurements from the same System.; Previous Releases: Updated Component part to harmonize with ISCN guidelines and current LOINC nomenclature.
Order vs. Observation
Both
Common Test Rank Get Info
5224

Formula (Readable)

IS % ratio = local % ratio x conversion factorwherelocal % ratio = 100 x BCR-ABL1/control gene

Member of these Panels

LOINCLong Common Name
72104-3Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Fúzní transkript t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2/kontrolní transkript (International Scale):Početní poměr:Časový bod:Krev/tkáň:Kvantitativní:Molekulární genetika
el-GRGreek (Greece)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 μεταγραφή συγχώνευσης/μεταγραφή ελέγχου (Διεθνής Κλίμακα):NRto:Pt:Αίμα/Ιστός:Qn:Μοριακή γενετική
Synonyms: MOLPATH MOLPATH.TRNLOC NRto Pt Qn t(9;22)(q34.1;q11)(ABL1,BCR) t(9;22)(q34.1;q11)(ABL1,BCR) b2a2 t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 Αίμα Αίμα/Ιστός Ιστός μεταγραφή ελέγχου (Διεθνής Κλίμακα) μεταγραφή συγχώνευσης Μοριακή γενετική
es-ESSpanish (Spain)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 Tránscritos de fusión/transcrito control (escala internacional):Relación de número:Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
es-MXSpanish (Mexico)t (9; 22) (q34.1; q11) (ABL1, BCR) transcripción de fusión b2a2 + b3a2 / transcripción de control (escala internacional):Proporción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-CAFrench (Canada)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 transcrit de fusion/Transcrit de contrôle (échelle internationale):Ratio de numérique:Temps ponctuel:Sang/Tissu:Quantitatif:Molgen
fr-FRFrench (France)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 transcript de fusion/transcrit de référence (échelle internationale):Nombre/Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
it-ITItalian (Italy)t(9,22)(q34.1,q11)(ABL1,BCR) b2a2+b3a2, trascritto di fusione/trascritto di controllo (Scala Internazionale):NRto:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
nl-NLDutch (Netherlands)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusietranscript/controle transcript (internationale schaal):aantalsverhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: molgen
pl-PLPolish (Poland)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 transkrypt fuzyjny/kontrolny transkrypt (skala międzynarodowa):współczynnik liczbowy:punkt w czasie:krew lub tkanka:ilościowy:genetyka molekularna
Synonyms: diagnostyka molekularna
ru-RURussian (Russian Federation)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 слияния транскрипт/контроль транскрипция (Международная Шкала):КолОтн:ТчкВрм:Кр/Тк:Колич:МолГен
Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TRTurkish (Turkey)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 füzyon transkript/kontrol transkripti (Uluslararası Ölçek):SayOr:Zmlı:Kan/Dk:Kant:Molgen
zh-CNChinese (China)t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 融合转录物/对照转录物 (国际标尺):计数型比率:时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: ABL CML JTK7 p150 v-abl Abelson murine leukemia viral oncogene homolog 1 v-abl Abelson 小鼠白血病病毒癌基因同源体 1 v-abl Abelson 小鼠白血病病毒肿瘤基因同源体 1 v-abl Abelson 小鼠白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科动物白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科白血病病毒致癌基因同源体 1 全血或组织;血液/组织;血液或组织 分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本;International Scale 慢性粒细胞性白血病 慢性粒细胞白血病 慢性粒细胞白血病（Chronic myeloid leukemia，CML） 慢性髓系白血病 断点簇集区 断裂点丛集区 断裂点簇集区 断裂点聚集区 断裂点集中区 断裂点集中区（Breakpoint cluster region，BCR） 时刻;随机;随意;瞬间 易位(9;22)(q34.1;q11)(ABL1,BCR) 易位(9;22)(q34.1;q11)(ABL1,BCR) b2a2 易位(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 未作说明的组织;组织;组织 & 涂片 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 血;血液 限制性断裂区

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=69380-4