69956-1

Human upstream binding factor IgG Ab [Presence] in Serum by Immunoassay

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Term Description

This entity has two names: "nucleolar organizing region (NOR) 90" versus "human upstream binding factor (hUBF)". Both names are right, and the literature looking for the antibody in autoimmune patients almost uniformly includes both names and the historical context. NOR90 stuck because it was called that by the author of the original finding in autoimmune patients (Rodriguez-Sanchez, et al, 1987), but a few years later (1994), the antigen was found to be identical to already characterized hUBF. So we are stuck with the 2 names. hUBF is more technically specific, and at least one recent review calls it "anti-hUBF, formerly anti-NOR 90" (Journal of Dermatology 2010; 37: 42-53). So we will use that as its primary name.

Part Description

LP71704-8 Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. PMID: 25965800 Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. PMID: 20175839 Source: Regenstrief LOINC, PMID: 20175839

LOINC Names Get Info

Fully-Specified Name: Human upstream binding factor Ab.IgG:PrThr:Pt:Ser:Ord:IA
Long Common Name: Human upstream binding factor IgG Ab [Presence] in Serum by Immunoassay
Short Name: hUBF IgG Ser Ql IA
Display Name: Human upstream binding factor IgG IA Ql (S)
Consumer Name Alpha Get Info: Human upstream binding factor IgG antibody, Blood

Part Model Get Info

Component
Human upstream binding factor Ab.IgG
LP145564-3
- Analyte
  Human upstream binding factor Ab.IgG
  LP145564-3
  - Component Numerator
    Human upstream binding factor Ab.IgG
    LP145564-3
    - Component Numerator Core
      Human upstream binding factor
      LP71704-8
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
IA
LP217197-5

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.40
Last Updated: Version 2.68 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Lidský faktor UBF IgG:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Imunoanalýza
de-AT	German (Austria)	Synonyms: NOR-90 IgG-AK ql.
el-GR	Greek (Greece)	Ανθρώπινος παράγοντας δέσμευσης ανάντη Αντισώματα IgG:PrThr:Pt:Ορός:Ord:IA Synonyms: IA Ord PrThr Pt SERO Ανθρώπινος παράγοντας δέσμευσης ανάντη Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Ορός
es-ES	Spanish (Spain)	factor de unión upstream humano IgG:PrThr:Punto temporal:Suero:Ord:IA
es-MX	Spanish (Mexico)	Factor de unión aguas arriba humano Ab.IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
et-EE	Estonian (Estonia)	NOR-90 antikehad.IgG:PrThr:Pt:S:Ord:IA Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Seerum
fr-CA	French (Canada)	NOR-90, IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR	French (France)	NOR-90 Ac IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	Human upstream binding factor Anticorps. IgG:PrThr:Temps ponctuel:Sérum:Ordinal:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Fattore umano a monte legante Ab.IgG:PrThr:Pt:Siero:Ord:IA Synonyms: anticorpi IgG anticorpo hUBF Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	Humaan upstream binding factor As.IgG:aanwezigheid:moment:serum:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
pt-BR	Portuguese (Brazil)	Fator de ligação upstream humano Ac.IgG:Limiar:Pt:Soro:Ord:Imunoensaio
ru-RU	Russian (Russian Federation)	Человеческий upstream binding factor Ат.IgG:PrThr:ТчкВрм:Сыв:Пор:IA Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Human upstream bağlayıcı factor Ab.IgG:MevcEşik:Zmlı:Ser:Srl:İA Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay Mevcut
zh-CN	Chinese (China)	人上游结合因子抗体.IgG:存在情况或阈值:时间点:血清:序数型:免疫测定法 Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体人上遊結合因子;人类上游结合因子;hUBF;Human upstream binding factor 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验免疫球蛋白 G 因素存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间系数结合性结合性的血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.