69956-1
Human upstream binding factor IgG Ab [Presence] in Serum by Immunoassay
Active
Term Description
This entity has two names: "nucleolar organizing region (NOR) 90" versus "human upstream binding factor (hUBF)". Both names are right, and the literature looking for the antibody in autoimmune patients almost uniformly includes both names and the historical context. NOR90 stuck because it was called that by the author of the original finding in autoimmune patients (Rodriguez-Sanchez, et al, 1987), but a few years later (1994), the antigen was found to be identical to already characterized hUBF. So we are stuck with the 2 names. hUBF is more technically specific, and at least one recent review calls it "anti-hUBF, formerly anti-NOR 90" (Journal of Dermatology 2010; 37: 42-53). So we will use that as its primary name.
Source: Regenstrief LOINC
Part Description
LP71704-8 Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. PMID: 25965800 Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. PMID: 20175839
Source: Regenstrief LOINC, PMID: 20175839
Fully-Specified Name
- Component
- Human upstream binding factor Ab.IgG
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IA
Additional Names
- Short Name
- hUBF IgG Ser Ql IA
- Display Name
- Human upstream binding factor IgG IA Ql (S)
- Consumer Name Alpha Get Info
- Human upstream binding factor IgG antibody, Blood
Example Answer List: LL360-9
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.40
- Last Updated
- Version 2.68
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: NOR-90 IgG-AK ql. |
| es-ES | Spanish (Spain) | factor de unión upstream humano IgG: |
| es-MX | Spanish (Mexico) | Factor de unión aguas arriba humano Ab.IgG: |
| et-EE | Estonian (Estonia) | NOR-90 antikehad.IgG: Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Seerum |
| fr-CA | French (Canada) | NOR-90, IgG: |
| fr-FR | French (France) | NOR-90 anticorps IgG: |
| fr-BE | French (Belgium) | Human upstream binding factor Anticorps. IgG: Synonyms: Anticorps |
| it-IT | Italian (Italy) | Fattore umano a monte legante Ab.IgG: Synonyms: anticorpi IgG anticorpo hUBF Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | Humaan upstream binding factor As.IgG: Synonyms: antistof; |
| pt-BR | Portuguese (Brazil) | Fator de ligação upstream humano Ac.IgG: |
| ru-RU | Russian (Russian Federation) | Человеческий upstream binding factor Ат.IgG: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | Human upstream bağlayıcı factor Ab.IgG: Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay Mevcut |
| zh-CN | Chinese (China) | 人上游结合因子 抗体.IgG: Synonyms: Ab.IgG; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=69956-1
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright