Version 2.77

Term Description

This entity has two names: "nucleolar organizing region (NOR) 90" versus "human upstream binding factor (hUBF)". Both names are right, and the literature looking for the antibody in autoimmune patients almost uniformly includes both names and the historical context. NOR90 stuck because it was called that by the author of the original finding in autoimmune patients (Rodriguez-Sanchez, et al, 1987), but a few years later (1994), the antigen was found to be identical to already characterized hUBF. So we are stuck with the 2 names. hUBF is more technically specific, and at least one recent review calls it "anti-hUBF, formerly anti-NOR 90" (Journal of Dermatology 2010; 37: 42-53). So we will use that as its primary name.
Source: Regenstrief LOINC

Part Description

LP71704-8   Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. PMID: 25965800 Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. PMID: 20175839 Source: Regenstrief LOINC, PMID: 20175839

Fully-Specified Name

Component
Human upstream binding factor Ab.IgG
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IA

Additional Names

Short Name
hUBF IgG Ser Ql IA
Display Name
Human upstream binding factor IgG IA Ql (S)
Consumer Name Alpha Get Info
Human upstream binding factor IgG antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.68
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: NOR-90 IgG-AK ql.
es-ES Spanish (Spain) factor de unión upstream humano IgG:PrThr:Punto temporal:Suero:Ord:IA
es-MX Spanish (Mexico) Factor de unión aguas arriba humano Ab.IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
et-EE Estonian (Estonia) NOR-90 antikehad.IgG:PrThr:Pt:S:Ord:IA
Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Seerum
fr-CA French (Canada) NOR-90 , IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR French (France) NOR-90 anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE French (Belgium) Human upstream binding factor Anticorps. IgG:PrThr:Temps ponctuel:Sérum:Ordinal:IA
Synonyms: Anticorps
it-IT Italian (Italy) Fattore umano a monte legante Ab.IgG:PrThr:Pt:Siero:Ord:IA
Synonyms: anticorpi IgG anticorpo hUBF Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) Humaan upstream binding factor As.IgG:aanwezigheid:moment:serum:ordinaal:immunoassay
Synonyms: antistof; antilichaam IA
pt-BR Portuguese (Brazil) Fator de ligação upstream humano Ac.IgG:Limiar:Pt:Soro:Ord:Imunoensaio
ru-RU Russian (Russian Federation) Человеческий upstream binding factor Ат.IgG:PrThr:ТчкВрм:Сыв:Пор:IA
Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Human upstream bağlayıcı factor Ab.IgG:MevcEşik:Zmlı:Ser:Srl:İA
Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay Mevcut
zh-CN Chinese (China) 人上游结合因子 抗体.IgG:存在情况或阈值:时间点:血清:序数型:免疫测定法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 人上遊結合因子;人类上游结合因子;hUBF;Human upstream binding factor 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 G 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 系数 结合性 结合性的 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目(非微生物学);血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验(非微生物学);血清学试验类 (非微生物学);血清类

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