Version 2.73

69956-1Human upstream binding factor IgG Ab [Presence] in Serum by ImmunoassayActive

Term Description

This entity has two names: "nucleolar organizing region (NOR) 90" versus "human upstream binding factor (hUBF)". Both names are right, and the literature looking for the antibody in autoimmune patients almost uniformly includes both names and the historical context. NOR90 stuck because it was called that by the author of the original finding in autoimmune patients (Rodriguez-Sanchez, et al, 1987), but a few years later (1994), the antigen was found to be identical to already characterized hUBF. So we are stuck with the 2 names. hUBF is more technically specific, and at least one recent review calls it "anti-hUBF, formerly anti-NOR 90" (Journal of Dermatology 2010; 37: 42-53). So we will use that as its primary name.
Source: Regenstrief LOINC

Part Description

LP71704-8   Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. [PMID:25965800] Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. [PMID:20175839] Source: Regenstrief LOINC, PMID: 20175839

Fully-Specified Name

Human upstream binding factor Ab.IgG

Additional Names

Short Name
hUBF IgG Ser Ql IA
Display Name
Human upstream binding factor IgG IA Ql (S)
Consumer Name Alpha
Human upstream binding factor IgG antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.40
Last Updated
Version 2.68
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
人上游结合因子 抗体.IgG:存在情况或阈值:时间点:血清:序数型:免疫测定法
nl-NLDutch (Netherlands)
Humaan upstream binding factor As.IgG:aanwezigheid:moment:serum:ordinaal:immunoassay
et-EEEstonian (Estonia)
NOR-90 antikehad.IgG:PrThr:Pt:S:Ord:IA
fr-BEFrench (Belgium)
Human upstream binding factor Anticorps. IgG:PrThr:Temps ponctuel:Sérum:Ordinal:IA
fr-CAFrench (Canada)
NOR-90 , IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FRFrench (France)
NOR-90 anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
it-ITItalian (Italy)
Fattore umano a monte legante Ab.IgG:PrThr:Pt:Siero:Ord:IA
pt-BRPortuguese (Brazil)
Fator de ligação upstream humano Ac.IgG:Limiar:Pt:Soro:Ord:Imunoensaio
ru-RURussian (Russian Federation)
Человеческий upstream binding factor Ат.IgG:PrThr:ТчкВрм:Сыв:Пор:IA
es-MXSpanish (Mexico)
Factor de unión aguas arriba humano Ab.IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
es-ESSpanish (Spain)
factor de unión upstream humano IgG:PrThr:Punto temporal:Suero:Ord:IA
tr-TRTurkish (Turkey)
Human upstream bağlayıcı factor Ab.IgG:MevcEşik:Zmlı:Ser:Srl:İA

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