LOINC
Version 2.67

70252-2Islet cell 512 IgG Ab [Presence] in Serum or Plasma by ImmunoassayActive

Term Description

This term was created for (but not limited to) EUROIMMUN's Anti-Tyrosine Phosphatase (IA2) quantitative ELISA (IgG) test system for the in vitro determination of antibodies against tyrosine phosphatase (IA2) in human serum or EDTA plasma for the diagnosis of diabetes mellitus type I.
Source: Regenstrief LOINC

Part Description

LP28780-2   Islet cell 512
Islet cell antigen (ICA) 512 is a receptor-tyrosine phosphatase-like protein associated with the secretory granules of neuroendocrine cells. ICA-512 is also known as protein tyrosine phosphatase-IA2 (PTP-IA2) or tyrosine phosphatase (IA2). It is an autoantigen of type 1 diabetes. This is NOT the same as pancreatic islet cell. Studies on type-1 diabetic patient's relatives found that the development of one or more islet autoantibodies (including IA-2 antibody) was an early indicator of the relatives' progression to type-1 diabetes. Autoantibody profiles identifying patients destined to develop type-1 diabetes are usually detectable before age three. One study found that for relatives seropositive for IA-2 antibody, the likelihood of developing type-1 diabetes mellitus within five-years was 65.3%. Some type-1 diabetic patients are originally diagnosed as having type-2 diabetes due to symptom onset in adulthood, societal obesity, and initial insulin-independence. Detection of one or more islet auto-antibodies (including IA-2) may be used to distinguish these patients with "latent autoimmune diabetes" from type-2 diabetics. Source: Regenstrief Institute

Fully-Specified Name

Component
Islet cell 512 Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
IA

Additional Names

Short Name
Islet Cell512 IgG SerPl Ql IA
Display Name
Islet cell 512 IgG IA Ql

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
岛细胞 512 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:免疫测定法
nl-NLDutch (NETHERLANDS)
islet antigeen-2 As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:immunoassay
fr-BEFrench (BELGIUM)
ICA 512 d'îlots de Langerhans Anticorps. IgG:PrThr:Temps ponctuel:Sérum/Plasma:Ordinal:IA
fr-CAFrench (CANADA)
ICA 512 d'îlots de Langerhans , IgG:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:IA
fr-FRFrench (FRANCE)
Cellules îlots 512 anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Immunoanalyse
it-ITItalian (ITALY)
Isola 512 cellula , Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:IA
pt-BRPortuguese (BRAZIL)
Ilhotas células 512 Ac.IgG:Limiar:Pt:Soro/Plas:Ord:Imunoensaio
ru-RURussian (RUSSIAN FEDERATION)
Островковая клетка 512 Ат.IgG:PrThr:ТчкВрм:Сыв/Плаз:Пор:IA
es-ESSpanish (SPAIN)
Célula de los islotes 512 IgG:PrThr:Punto temporal:Suero o Plasma:Ord:IA
tr-TRTurkish (TURKEY)
Adacık hücresi 512 Ab.IgG:MevcEşik:Zmlı:Ser/Plaz:Srl:İA

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=70252-2