Version 2.78

Part Descriptions

LP16737-6   Rabies virus
Rabies virus (RV), is an enveloped, single-stranded, negative sense RNA virus and a member of the Rhabdoviridae family. It is transmitted when an animal infected with RV bites an individual or the saliva from an infected animal comes into contact with an open wound. Once RV penetrates the muscle or connective tissue it begins to replicate and then infiltrates the peripheral nerves through the neuromuscular junction. From there, RV spreads to the central nervous system (CNS) in the endoneurium of the Schwann cells. If bitten by an animal that may have RV infection, rabies immune globulin and rabies vaccine should be administered. Otherwise, there is no treatment for infection by RV other than supportive care, and acute infection of the CNS is almost always fatal. In countries where preventative care is not practiced, RV is still widespread. In Asia, 30,000 people die annually from RV infection. Diagnosis of RV is done on two tissue specimens from the brain that are analyzed by direct fluorescent antibody (DFA), mouse inoculation, tissue culture and polymerase chain reaction.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307483/] Source: Regenstrief LOINC

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

Fully-Specified Name

Component
Rabies virus Ab.Neut
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Neut

Additional Names

Short Name
RABV NAb Ser Ql Nt
Display Name
Rabies virus neut ab Neut test Ql (S)
Consumer Name Alpha Get Info
Rabies virus neutralizing antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.72
Change Reason
Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG32755-7 Rabies virus

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Virus de la Rabia Anticuerpos antineutrófilos:PrThr:Punto temporal:Suero:Ord:Prueba de neutralización
es-MX Spanish (Mexico) Virus de la rabia Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Prueba de neutralización
fr-FR French (France) Rage virus Ac neutralisant:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Neutralisation
fr-CA French (Canada) Virus de la rage Ac.neut:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Test de neutralisation
it-IT Italian (Italy) Rabbia, virus Ab.Neut:PrThr:Pt:Siero:Ord:Neut
Synonyms: anticorpo Microbiologia Presenza o Soglia Punto nel tempo (episodio) Siero Test di neutralizzazione Virus della rabbia
nl-NL Dutch (Netherlands) rabiësvirus As.neutraliserend:aanwezigheid:moment:serum:ordinaal:neutralisatietest
Synonyms: antistof; antilichaam hondsdolheidsvirus; Rabies lyssavirus; RABV
pl-PL Polish (Poland) Wirus wścieklizny Ab.Neutralizujące:granica wykrywalności:punkt w czasie:surowica:półilościowy:test neutralizacji
Synonyms: Przeciwciała do wirusa wścieklizny Przeciwciała neutralizujące do wirusa wścieklizny
pt-BR Portuguese (Brazil) Raiva vírus Ac:Limiar:Pt:Soro:Ord:
zh-CN Chinese (China) 狂犬病病毒 抗体.中和:存在情况或阈值:时间点:血清:序数型:中和试验
Synonyms: Ab;自身抗体 RABV Ab RABV 抗体 RABV;儿犬病;恐水病;狂犬病;狂犬病毒;麻痹型狂犬病 中和试验;中和抗体;中和 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 狂犬病毒 Ab 狂犬病毒抗体 狂犬病病毒 Ab

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=70858-6