70907-1

Cryptococcus sp rRNA gene [Identifier] in Specimen by Sequencing

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Term Description

PCR alone is not sufficient to identify Cryptococcus species. Most most labs would use a generic fungal primer and then sequence to get the actual species. C. neoformans, C. gattii, and C. grubii can be distinguished by sequencing.

Part Descriptions

LP147271-3   Cryptococcus sp rRNA gene
Cryptococcus species are encapsulated yeast that cause cryptococcosis, an opportunistic infection that primary affects patients who are immunocompromised. Manifestations of Cryptococcus infection include meningitis and pulmonary cryptococcosis. Analysis of the DNA encoding the ribosomal RNA, sometimes referred to as rDNA, can differentiate among pathogenic yeast, such as Candida and Cryptococcus, and can also be used to identify specific species, such as Cryptococcus neoformans and C. gattii, depending on the specific region that is targeted. PMID: 28260588 Source: Regenstrief LOINC

LP150045-5   Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

Fully-Specified Name

Component

Cryptococcus sp rRNA gene

Property

Prid

Time

Pt

System

XXX

Scale

Nom

Method

Sequencing

Additional Names

Long Common Name

Cryptococcus sp rRNA gene [Identifier] in Specimen by Sequencing

Short Name

Crypt sp rRNA gene Spec Seq

Display Name

Cryptococcus sp rRNA Sequencing Nom (Specimen)

Consumer Name Alpha Get Info

Cryptococcus species rRNA, Specimen

Example Answer List: LL2068-6

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.40

Last Updated

Version 2.69 (MIN)

Change Reason

Corrected Component from 'Cryptococcus sp rDNA' to 'Cryptococcus sp rRNA gene' to represent what is being measured (the gene encoding ribosomal RNA)

Order vs. Observation

Both

Language Variants Get Info

Related Names

• Crypt
• Crypt sp rRNA gene
• Crypto
• Cryptococcal
• Cryptococcosis
• Cryptococcosus
• high-throughput sequencing
• HTS
• ID
• Identity or presence
• Infectious Disease
• InfectiousDisease
• Microbiology
• Misc
• Miscellaneous
• Next generation sequencing
• NGS
• Nominal
• Other
• Point in time
• Random
• rDNA
• ribosomal RNA
• Spec
• species
• spp
• To be specified in another part of the message
• Unspecified

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=70907-1

LOINC Copyright

Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.