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Term Description

PCR alone is not sufficient to identify Cryptococcus species. Most most labs would use a generic fungal primer and then sequence to get the actual species. C. neoformans, C. gattii, and C. grubii can be distinguished by sequencing.

Part Descriptions

LP147271-3   Cryptococcus sp rRNA gene
Cryptococcus species are encapsulated yeast that cause cryptococcosis, an opportunistic infection that primary affects patients who are immunocompromised. Manifestations of Cryptococcus infection include meningitis and pulmonary cryptococcosis. Analysis of the DNA encoding the ribosomal RNA, sometimes referred to as rDNA, can differentiate among pathogenic yeast, such as Candida and Cryptococcus, and can also be used to identify specific species, such as Cryptococcus neoformans and C. gattii, depending on the specific region that is targeted. PMID: 28260588 Source: Regenstrief LOINC

LP150045-5   Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Cryptococcus sp rRNA gene:Prid:Pt:XXX:Nom:Sequencing
Long Common Name
Cryptococcus sp rRNA gene [Identifier] in Specimen by Sequencing
Short Name
Crypt sp rRNA gene Spec Seq
Display Name
Cryptococcus sp rRNA Sequencing Nom (Specimen)
Consumer Name Alpha Get Info
Cryptococcus species rRNA, Specimen

Part Model Get Info

  • Component
    Cryptococcus sp rRNA gene
    LP147271-3
    • Analyte
      Cryptococcus sp rRNA gene
      LP147271-3
      • Component Numerator
        Cryptococcus sp rRNA gene
        LP147271-3
        • Component Numerator Core
          Cryptococcus sp rRNA gene
          LP147271-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    XXX
    LP7735-6
    • System Core
      XXX
      LP7735-6
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Sequencing
    LP150045-5

Example Answer List: LL2068-6

Source: Centers for Disease Control and Prevention
AnswerCodeScoreAnswer ID
C neoformansLA18527-4
C gattiiLA18528-2
C grubiiLA18529-0

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.69 (MIN)
Change Reason
Corrected Component from 'Cryptococcus sp rDNA' to 'Cryptococcus sp rRNA gene' to represent what is being measured (the gene encoding ribosomal RNA)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Cryptococcus sp gen rRNA:Přítomnost nebo identita:Časový bod:XXX:Nominální:Sekvenace
el-GRGreek (Greece)Γονίδιο rRNA Cryptococcus sp:Prid:Pt:XXX:Nom:Αλληλούχιση
Synonyms: MICRO Nom Prid Pt XXX Αλληλούχιση Γονίδιο Γονίδιο rRNA Cryptococcus sp Μύκητας Cryptococcus sp
es-ESSpanish (Spain)Gen rRNA de Crytococcus sp:Presencia o identidad:Punto temporal:XXX:Nom:Secuenciación
es-MXSpanish (Mexico)Gen de ARNr de Cryptococo sp:Presencia o identidad:Punto temporal:XXX:Nominal:Secuenciación
fr-FRFrench (France)Cryptococcus ARNr gène:Identification:Ponctuel:Milieux divers:Résultat nominal:Séquençage
it-ITItalian (Italy)Cryptococcus sp, gene rRNA:Prid:Pt:XXX:Nom:Sequenziamento
Synonyms: Microbiologia Presenza o Identità Punto nel tempo (episodio)
nl-NLDutch (Netherlands)Cryptococcus sp. rRNA-gen:identificator:moment:XXX:nominaal:sequencing
pl-PLPolish (Poland)Cryptococcus sp rRNA gen:obecność lub identyfikacja:punkt w czasie:XXX:skala nominalna:sekwencjonowanie
Synonyms: Gen rRNA Cryptococcus sp wynik kategorialny
pt-BRPortuguese (Brazil)Cryptococcus sp rDNA:Ident:Pt:XXX:Nom:Sequenciamento
zh-CNChinese (China)隐球菌属 rRNA 基因:存在与否或特征标识:时间点:XXX:名义型:序列测定
Synonyms: 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 克里氏综合症 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 存在;存在与否;特征标识;身份;身份标识 布-布二氏病 序列分析;测序 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 新型隐球菌病 时刻;随机;随意;瞬间 核蛋白体 RNA 核蛋白体 RNA（Ribosomal RNA，RRNA） 核蛋白体核糖核酸 核醣体 RNA 物种 生物种 遗传基因;遗传因子;吉恩;生物基因 隐球菌 rRNA 基因;隐球酵母 rRNA 基因;隐球酵母属 rRNA 基因;隐球酵母菌 rRNA 基因;隐球酵母菌属 rRNA 基因;隐球菌病;隐球酵母菌病 隐球菌;隐球菌病;隐球酵母;隐球酵母属;隐球酵母菌;隐球酵母菌属;隐球酵母菌病;隐球菌单个未知种 隐球菌病 隐球酵母

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