Log In

Term Description

Translocations between chromosomes 8 and 21, resulting in a fused transcript between RUNXT1 (8q22) and RUNX1 (21q22.3), can be detected with real-time PCR. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.

Part Description

LP19847-0   t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
Translocation (8;21) resulting in a fused transcript between RUNX1T1 (also known as ETO) and RUNX1 genes is one of the most common chromosomal translocations found in acute myeloid leukemia (AML). The RUNX1T1-RUNX1 fusion transcript is found in approximately 12% of all AML patients. RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis and is essential in defining the final hematopoietic stem cell. It is involved in many forms of chromosomal translocations in leukemia. In addition, many hematological diseases have been associated with mutations in RUNX1. PMID: 22201794 Source: Regenstrief LOINC, PMID: 22201794

LOINC Names Get Info

Fully-Specified Name
t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript:NRto:Pt:Bld/Tiss:Qn:Molgen
Long Common Name
t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Short Name
t(8;21)(RUNX1T1,RUNX1)/control Bld/T
Display Name
t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Consumer Name Alpha Get Info
t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)/control Transcript, Blood or tissue specimen

Part Model Get Info

  • Component
    t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript
    LP287176-4
    • Analyte
      t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript
      LP287176-4
      • Component Numerator
        t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript
        LP229761-4
        • Component Numerator Core
          t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
          LP19847-0
        • Component Numerator Core Suffix
          fusion transcript
          LP150217-0
      • Component Denominator
        control transcript
        LP150246-9
        • Component Denominator Core
          control transcript
          LP150246-9
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NRto
    LP6840-5
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Molgen
    LP6404-0

Basic Attributes

Class
MOLPATH.TRNLOC
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
6138

Formula (Readable)

Normalized copy number (NCN) = Fusion gene copy number (FGCN) / Control gene copy number (CGCN)

Member of these Panels

LOINCLong Common Name
72104-3Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Fúzní transkript t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)/kontrolní transkript:Početní poměr:Časový bod:Krev/tkáň:Kvantitativní:Molekulární genetika
el-GRGreek (Greece)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) μεταγραφή συγχώνευσης/μεταγραφή ελέγχου:NRto:Pt:Αίμα/Ιστός:Qn:Μοριακή γενετική
Synonyms: MOLPATH MOLPATH.TRNLOC NRto Pt Qn t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) Αίμα Αίμα/Ιστός Ιστός μεταγραφή ελέγχου μεταγραφή συγχώνευσης Μοριακή γενετική
es-ESSpanish (Spain)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) Tránscritos de fusión/transcrito control:Relación de número:Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
es-MXSpanish (Mexico)t (8; 21) (q22; q22.3) (RUNX1T1, RUNX1) transcripción de fusión / transcripción de control:Proporción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-FRFrench (France)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) transcript de fusion/transcrit de référence:Nombre/Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
fr-CAFrench (Canada)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) transcrit de fusion/Transcrit de contrôle:Ratio de numérique:Temps ponctuel:Sang/Tissu:Quantitatif:Molgen
it-ITItalian (Italy)t(8,21)(q22,q22.3)(RUNX1T1,RUNX1), trascritto di fusione/trascritto di controllo:NRto:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
nl-NLDutch (Netherlands)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusietranscript/controle transcript:aantalsverhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: molgen
pl-PLPolish (Poland)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) transkrypt fuzyjny/transkrypt kontrolny:współczynnik liczbowy:punkt w czasie:krew lub tkanka:ilościowy:genetyka molekularna
Synonyms: diagnostyka molekularna
ru-RURussian (Russian Federation)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) слияния транскрипт/контрольный транскрипт:КолОтн:ТчкВрм:Кр/Тк:Колич:МолГен
Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TRTurkish (Turkey)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) füzyon transkript/kontrol transkripti:SayOr:Zmlı:Kan/Dk:Kant:Molgen
zh-CNChinese (China)t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) 融合转录物/对照转录物:计数型比率:时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: AML1 CDR ETO MGC2796 MTG8 RUNX1T1 T(8,21)(CBFA2T1,CBFA2) 基因易位;T(8,21)(CBFA2T1,CBFA2) 易位 ZMYND2 全血或组织;血液/组织;血液或组织 分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本 急性髓性白血病 1 急性髓性白血病 1 易位 1, 细胞周期蛋白-D 相关性 急性髓性白血病 1 染色体易位 1, 细胞周期蛋白-D 相关性 急性髓系白细胞 1 急性髓系白细胞 1 易位 1, 细胞周期蛋白-D 相关性 急性髓系白细胞 1 易位 1, 细胞周期蛋白-D 相关性（Acute myelogenous leukemia 1 translocation 1, cyclin-D related） 急性髓系白细胞 1 染色体易位 1, 细胞周期蛋白-D 相关性 急性髓系白细胞 1（Acute myeloid leukemia 1） 急性髓细胞白血病 1 急性髓细胞白血病 1 易位 1, 细胞周期蛋白-D 相关性 急性髓细胞白血病 1 染色体易位 1, 细胞周期蛋白-D 相关性 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染色体 8q22 之上的 AML1T1L 髓系易位基因 核心结合因子侏儒结构域 alpha 亚基 2 核心结合因子侏儒结构域α亚基 2 核心结合因子矮小域 alpha 亚基 2 核心结合因子矮小域α亚基 2 核心结合因子矮小结构域 alpha 亚基 2 核心结合因子矮小结构域 alpha 亚基 2（Core binding factor runt domain alpha subunit 2） 核心结合因子矮小结构域α亚基 2 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 血;血液

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72207-4