72323-9

HLA-DP+DQ+DR (class II) IgG Ab [Presence] in Serum by Flow cytometry (FC)

Active

Term Description

IgG antibodies to HLA class II antigens (DP, DQ, and DR) can be detected by flow cytometry in serum of pre and post-transplant organ recipients. A positive result is an indication of a sensitization to HLA antigens. This code is based on, but not exclusive to, the submitter's test kit, One Lambda's FlowPRA Screening Test, which uses beads coated with common and rare purified HLA Class I or II antigens.

Part Description

LP156721-5 HLA-DP+DQ+DR Ab.IgG
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.

Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: HLA-DP+DQ+DR Ab.IgG:PrThr:Pt:Ser:Ord:Flow cytometry
Long Common Name: HLA-DP+DQ+DR (class II) IgG Ab [Presence] in Serum by Flow cytometry (FC)
Short Name: HLA-DP+DQ+DR IgG Ser Ql FC
Display Name: HLA-DP+DQ+DR (class II) IgG FC Ql (S)
Consumer Name Alpha Get Info: HLA-DP+DQ+DR (class II) IgG antibody, Blood

Part Model Get Info

Component
HLA-DP+DQ+DR Ab.IgG
LP156721-5
- Analyte
  HLA-DP+DQ+DR Ab.IgG
  LP156721-5
  - Component Numerator
    HLA-DP+DQ+DR Ab.IgG
    LP156721-5
    - Component Numerator Core
      HLA-DP+DQ+DR
      LP56928-2
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Flow cytometry
LP6274-7

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: HLA
Type: Laboratory
First Released: Version 2.42
Last Updated: Version 2.56 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
94428-0	HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC)
94440-5	HLA-DP and DQ and DR (class II) IgG panel - Serum or Plasma by Flow cytometry (FC)
72905-3	Neutrophil Ab and HLA Ab screen panel - Serum or Plasma

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	HLA-DP+DQ+DR IgG:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Průtoková cytometrie
el-GR	Greek (Greece)	Ανθρώπινα λευκοκυτταρικά αντιγόνα-DP+DQ+DR Αντισώματα IgG:PrThr:Pt:Ορός:Ord:Κυτταρομετρία ροής Synonyms: dP Ord PrThr Pt Ανθρώπινα λευκοκυτταρικά αντιγόνα Ανθρώπινα λευκοκυτταρικά αντιγόνα-DP Ανθρώπινα λευκοκυτταρικά αντιγόνα-DP+DQ+DR Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Κυτταρομετρία ροής Ορός
es-ES	Spanish (Spain)	HLA-DP+DQ6DR IgG:PrThr:Punto temporal:Suero:Ord:Citometria de flujo (FC)
es-MX	Spanish (Mexico)	HLA-DP + DQ + DR Ab.IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Citometría de flujo (FC)
et-EE	Estonian (Estonia)	HLA-DP+DQ+DR antikehad.IgG:PrThr:Pt:S:Ord:Voolutsütomeetria Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Seerum
fr-CA	French (Canada)	HLA-DP+DQ+DR, IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Cytométrie de flux
fr-FR	French (France)	HLA-DP+DQ+DR Ac IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Cytométrie de flux
fr-BE	French (Belgium)	HLA-DP+DQ+DR Anticorps. IgG:PrThr:Temps ponctuel:Sérum:Ordinal:Cytométrie de flux Synonyms: Anticorps
it-IT	Italian (Italy)	HLA-DP+DQ+DR Ab.IgG:PrThr:Pt:Siero:Ord:Citometria a flusso Synonyms: anticorpi IgG anticorpo Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi Presenza o Soglia Pressione differenziale Punto nel tempo (episodio) Siero
nl-NL	Dutch (Netherlands)	HLA-DP+DQ+DR As.IgG:aanwezigheid:moment:serum:ordinaal:flowcytometrie Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	HLA-DP+DQ+DR Ab.IgG:granica wykrywalności:punkt w czasie:surowica:uporządkowany:cytometria przepływowa (FC) Synonyms: HLA-DP, DQ i DR IgG Przeciwciała do HLA-DP+DQ+DR przeciwciała IgG Przeciwciała IgG do HLA-DP, DQ i DR
pt-BR	Portuguese (Brazil)	HLA-DP+DQ+DR Ac.IgG:Limiar:Pt:Soro:Ord:Citometria de fluxo
ru-RU	Russian (Russian Federation)	HLA-DP+DQ+DR Ат.IgG:PrThr:ТчкВрм:Сыв:Пор:Проточная цитометрия Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	HLA-DP+DQ+DR Ab.IgG:MevcEşik:Zmlı:Ser:Srl:Akış sitometri Synonyms: Ak Ak.IgG Akış hücremetresi Mevcut
zh-CN	Chinese (China)	HLA-DP+DQ+DR 抗体.IgG:存在情况或阈值:时间点:血清:序数型:流式细胞测量术 Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 HLA II 类;II 类 HLA HLA 抗原;人类白细胞抗原;human leukocyte antigen HLA-DP+DQ+DR Ab 人白细胞抗原人类白细胞抗原人类白细胞抗原（Human Leukocyte Antigen，HLA）依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫球蛋白 G 动态存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间流流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计白细胞抗原

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.