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Term Description

In the absence of anti-Infliximab antibodies, the Infliximab drug level typically reflects the total Infliximab concentration in serum. In the presence of anti-Infliximab antibodies, the Infliximab drug level typically reflects the antibody-unbound fraction of Infliximab concentration in serum.

Part Descriptions

LP158087-9   inFLIXimab Ab
Antibodies to infliximab (ATI) are detectable in 20% of pediatric and young adult patients taking infliximab. Patients with ATI have reduced levels of infliximab and a higher risk for surgery in patient with inflammatory bowel disease (IBD). When treatment with infliximab is combined with immunomodulators, the likelihood of developing ATI is reduced when compared to using infliximab alone. PMID: 25569737 Source: Regenstrief LOINC

LP35095-6   inFLIXimab
Infliximab is a genetically engineered immunoglobulin 1 murine-human chimeric monoclonal antibody against tumor necrosis factor alpha (TNFα). The murine portion is the part of the antibody that binds to TNFα while the human portion preserves functional immune capacity. Infliximab is used to treat Crohn's disease and, in particular, in treating the closure of intestinal or perianal fistulas in patients with acute intestinal involvement who have been unresponsive to other treatments. TNFα is a cytokine that acts to increase the inflammatory process in CD, RA, psoriasis and spondylarthropathy. The primary mechanism of infliximab is to combine with the inactivate soluble transmembrane TNFα. However, infliximab also modulates TNFα-producing cells through complement fixation of antibody-dependent T lymphocytes and monocytes by binding them to the IgG1 fc portion of infliximab. There is also a subsequent down-regulation of other inflammation-producing cytokines and a reduction of the level of chemokines and endothelial adhesion molecules. Negative side effects of infliximab include fibrostenosing CD and sepsis. PMID: 18360638 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
inFLIXimab Ab:MCnc:Pt:Ser/Plas:Qn:
Long Common Name
inFLIXimab Ab [Mass/volume] in Serum or Plasma
Short Name
inFLIXimab Ab SerPl-mCnc
Display Name
inFLIXimab Ab [Mass/Vol]
Consumer Name Alpha Get Info
inFLIXimab antibody, Blood

Part Model Get Info

  • Component
    inFLIXimab Ab
    LP158087-9
    • Analyte
      inFLIXimab Ab
      LP158087-9
      • Component Numerator
        inFLIXimab Ab
        LP158087-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
9310

Member of these Panels

LOINCLong Common Name
103791-0Infliximab and Infliximab Ab Panel - Serum or Plasma

Member of these Groups Get Info

LOINC GroupGroup Name
LG27918-8Infliximab Ab|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Infliximab Ab:Hmotnostní koncentrace:Časový bod:Sérum/plazma:Kvantitativní:
de-ATGerman (Austria)Synonyms: Infliximab-Antikörper
de-DEGerman (Germany)Infliximab Ak:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
el-GRGreek (Greece)Ινφλιξιμάμπη Αντίσωμα:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc Pt Qn SERO Αντίσωμα Ινφλιξιμάμπη Ορός Ορός/Πλάσμα Πλάσμα
es-ESSpanish (Spain)Infliximab Anticuerpos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)inFLIXimab Ab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EEEstonian (Estonia)Infliksimaab antikehad:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CAFrench (Canada)Infliximab, Ac:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FRFrench (France)Infliximab Ac:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BEFrench (Belgium)Infliximab Ac:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: Anticorps
it-ITItalian (Italy)Infliximab Ab:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: anticorpo Concentrazione di Massa Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)infliximab As:massa/volume:moment:serum of plasma:kwantitatief:
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Infliksymab Ab:stężenie masowe:punkt w czasie:surowica lub osocze:ilościowy:
Synonyms: Przeciwciała do Infliksymab
ru-RURussian (Russian Federation)Инфликсимаб Ат:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Антитело Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TRTurkish (Turkey)İnfliksimab Ab:KütlKons:Zmlı:Ser/Plaz:Kant:
Synonyms: Ak
zh-CNChinese (China)英利昔单抗 抗体:质量浓度:时间点:血清/血浆:定量型:
Synonyms: Ab;自身抗体 Infliximab 单抗;嵌合了肿瘤坏死因子α（TNF-α）的单克隆抗体;目前主要用于治疗类风湿性关节炎（RA）和克隆病（CD）;英利昔;英利昔单克隆抗体;因福利美;抗炎单克隆抗体 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆

Example Units

UnitSource
ng/mLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72623-2