72676-0
Sirolimus [Mass/volume] in Plasma --trough
Active
Part Descriptions
LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety.
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Source: Wikipedia,
Trough levels for therapeutic drug monitoring
LP21368-3 Sirolimus
Sirolimus, also known as rapamycin, is a macrolide compound that inhibits lymphocyte proliferation and is used as an immunosuppressant to prevent rejection in organ transplantation. It inhibits T-cell activation and proliferation by inhibiting the response to interleukin 2 (IL-2). Its mode of action differs from that of other immunosuppressants (SN Sehga, Clin Biochem, 31:335, 1998) most notably by not being a calcineurin inhibitor. Its inhibitory action is mediated via a cytosolic protein, FK-binding protein 12. Sirolimus is variably absorbed; levels need to monitored to achieve the therapeutic target while avoiding toxic levels. Sirolimus is marketed under the trade name Rapamune.
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- Sirolimus^trough:
MCnc: Pt: Plas: Qn: - Long Common Name
- Sirolimus [Mass/volume] in Plasma --trough
- Short Name
- Sirolimus Trough Plas-mCnc
- Display Name
- Sirolimus trough (P) [Mass/Vol]
- Consumer Name Alpha Get Info
- Sirolimus trough, Blood
Part Model Get Info
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.42
- Last Updated
- Version 2.42 (MIN)
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Sirolimus^Údolní koncentrace: |
| de-AT | German (Austria) | Synonyms: Sirolimus (TAL) |
| el-GR | Greek (Greece) | Σιρόλιμους^ελάχιστα επίπεδα: Synonyms: DRUG/TOX MCnc Pt Qn ελάχιστα επίπεδα Πλάσμα Σιρόλιμους |
| es-ES | Spanish (Spain) | Sirolimus^Valle monitorización terapéutica de fármacos: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Sirolimus ^ a través: |
| et-EE | Estonian (Estonia) | Siroliimus^baas: Synonyms: Juhuslik Kvantitatiivne Plasma |
| fr-CA | French (Canada) | Sirolimus^Creux: |
| fr-FR | French (France) | Sirolimus^taux résiduel: |
| fr-BE | French (Belgium) | Sirolimus^Creux: Synonyms: Minimum, nadir |
| it-IT | Italian (Italy) | Sirolimus^valore minimo: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) valore minimo TDM |
| nl-NL | Dutch (Netherlands) | sirolimus^dalspiegel: |
| ru-RU | Russian (Russian Federation) | Сиролимус^остаточная концентрация: Synonyms: Количественный Массовая концентрация минимум концентрации Плазма Рапамицин Точка во времени; |
| tr-TR | Turkish (Turkey) | Sirolimus^en düşük: Synonyms: çukur düzey |
| zh-CN | Chinese (China) | 西罗莫司^波谷: Synonyms: 一剂药物的初始剂量; |
Example Units
| Unit | Source |
|---|---|
| mg/L | Example UCUM Units |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://