72726-3

t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript [Identifier] in Blood or Tissue by FISH Nominal

Active

Term Description

Labs may report the X number of cells that have the translocation, t(4;14)(p16;q32), out of Y number of cells (e.g. 80 out of 100 cells, or 80%). Results are typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format.

Part Descriptions

LP157496-3 t(4;14)(p16;q32)(FGFR3,IGH)
The t(4;14)(p16;q32)(FGFR3,IGH) is detected by FISH and PCR methods, but poorly analyzed by conventional cytogenetic methods (e.g. karyotyping). The breakpoints on chromosome 4 occur within a 113-kb gene cluster region involving the fibroblast growth factor receptor 3 (FGFR3) gene. The fusion results in overexpression and activation of FGFR3, which causes oncogenic signal enhancing cell proliferation and survival. The t(4;14) translocation provides important prognostic information in patients with plasma cell myeloma. It is often associated with poor survival and poor response to chemotherapy. Source: Regenstrief LOINC

LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name: t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript:Prid:Pt:Bld/Tiss:Nom:FISH
Long Common Name: t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript [Identifier] in Blood or Tissue by FISH Nominal
Short Name: t(4;14)(FGFR3,IGH) Bld/T FISH
Display Name: t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript FISH Nom (Bld/Tiss)
Consumer Name Alpha Get Info: t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript analysis, Blood or tissue specimen

Part Model Get Info

Component
t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript
LP229755-6
- Analyte
  t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript
  LP229755-6
  - Component Numerator
    t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript
    LP229755-6
    - Component Numerator Core
      t(4;14)(p16;q32)(FGFR3,IGH)
      LP157496-3
    - Component Numerator Core Suffix
      fusion transcript
      LP150217-0
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Prid
LP6850-4
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld/Tiss
LP7061-7
- System Core
  Bld/Tiss
  LP7061-7
- Super System
  NULL
Scale
Nom
LP7750-5
Method
FISH
LP62864-1

Example Answer List: LL2356-5

Source: Estonian Society of Laboratory Medicine

Answer	Code	Score	Answer ID
(4p16,14q32)x2[100]			LA19546-3
t(4;14)(p16;q32)[x80]/(4p16,14q32)x2[20]			LA19545-5

Basic Attributes

Class: MOLPATH.TRNLOC
Type: Laboratory
First Released: Version 2.42
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 16312

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Fúzní transkript t(4;14)(p16;q32)(FGFR3,IGH):Přítomnost nebo identita:Časový bod:Krev/tkáň:Nominální:Fluorescenční in situ hybridizace (FISH)
el-GR	Greek (Greece)	t(4;14)(p16;q32)(FGFR3,IGH) μεταγραφή συγχώνευσης:Prid:Pt:Αίμα/Ιστός:Nom:Φθορίζουσα υβριδοποίηση in situ Synonyms: MOLPATH MOLPATH.TRNLOC Nom Prid Pt t(4;14)(p16;q32)(FGFR3,IGH) Αίμα Αίμα/Ιστός Ιστός μεταγραφή συγχώνευσης Φθορίζουσα υβριδοποίηση in situ
es-ES	Spanish (Spain)	t(4;14)(p16;q32)(FGFR3,IGH) Tránscritos de fusión:Presencia o identidad:Punto temporal:Sangre o tejido:Nom:Hibridación in situ fluoresente (FISH)
es-MX	Spanish (Mexico)	t (4; 14) (p16; q32) (FGFR3, IGH) transcrito de fusión:Presencia o identidad:Punto temporal:Sangre o tejido:Nominal:Hibridación fluorescente in situ (FISH)
fr-FR	French (France)	t(4;14)(p16;q32)(FGFR3,IGH) transcript de fusion:Identification:Ponctuel:Sang/Tissu:Résultat nominal:FISH
fr-CA	French (Canada)	t(4;14)(p16;q32)(FGFR3,IGH) transcrit de fusion:Présence ou identité:Temps ponctuel:Sang/Tissu:Nominal:Hybridation fluorescente in situ
it-IT	Italian (Italy)	t(4,14)(p16,q32)(FGFR3,IGH), trascritto di fusione:Prid:Pt:Sangue/Tess:Nom:FISH Synonyms: Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
nl-NL	Dutch (Netherlands)	t(4;14)(p16;q32)(FGFR3,IGH) fusietranscript:identificator:moment:bloed of weefsel:nominaal:FISH
pl-PL	Polish (Poland)	t (4; 14) (p16; q32) (FGFR3,IGH) transkrypt fuzyjny:obecność lub identyfikacja:punkt w czasie:krew lub tkanka:skala nominalna:FISH Synonyms: fluorescencyjna hybrydyzacja in situ Translokacja (4; 14) (p16; q32) (FGFR3,IGH) Translokacja (4; 14) (p16; q32) (FGFR3,IGH) transkrypt genu fuzyjnego wynik kategorialny
pt-BR	Portuguese (Brazil)	t(4;14)(p16;q32)(FGFR3,IGH) transcrição de fusão:Ident:Pt:Sg/Tecido:Nom:FISH
tr-TR	Turkish (Turkey)	t(4;14)(p16;q32)(FGFR3,IGH) füzyon transkript:MevcKimlik:Zmlı:Kan/Dk:Snf:FISH
zh-CN	Chinese (China)	t(4;14)(p16;q32)(FGFR3,IGH) 融合转录物:存在与否或特征标识:时间点:全血/组织:名义型:FISH Synonyms: Fluorescent in situ hybridization;荧光原位杂交全血或组织;血液/组织;血液或组织分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位分子病理学;分子病理学试验分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答存在;存在与否;特征标识;身份;身份标识时刻;随机;随意;瞬间易位(4;14)(p16;q32)(FGFR3,IGH) 未作说明的组织;组织;组织 & 涂片融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录血;血液

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72726-3

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.