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Part Description

LP417565-1   CYP1A2 gene allele
Genetic screening for abnormal CYP1A2 metabolism is focused on the presence of *1C (-3860G>A), *1F (163C>A) and *1K (-729C>T) genetic polymorphisms. Individuals homozygous for *1F have higher CYP1A2 activity in the presence of CYP1A2 inducers. The *1C and *1K alleles are associated with decreased CYP1A2 activity with intermediate metabolism when 1 allele is present and slow (poor) metabolism when 2 alleles are present. Inducers for CYP1A2 activity include smoking, coffee, omeprazole, insulin. Inhibitors include oral contraceptives. The genotype results may be used to determine a patient's drug dose adjustment. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
CYP1A2 gene allele:Geno:Pt:Bld/Tiss:Nom:Molgen
Long Common Name
CYP1A2 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
Short Name
CYP1A2 allele Geno Bld/T
Display Name
CYP1A2 gene allele genotype Molgen (Bld/Tiss)
Consumer Name Alpha Get Info
CYP1A2 gene allele genotype, Blood or tissue specimen

Part Model Get Info

  • Component
    CYP1A2 gene allele
    LP417565-1
    • Analyte
      CYP1A2 gene allele
      LP417565-1
      • Component Numerator
        CYP1A2 gene allele
        LP417565-1
        • Component Numerator Core
          CYP1A2 gene allele
          LP417565-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Geno
    LP345004-8
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Molgen
    LP6404-0

Example Answer List: LL2235-1

Source: Regenstrief LOINC
AnswerCodeScoreAnswer ID
CYP1A2 *1C/*1CLA19108-2
CYP1A2 *1F/*1FLA19106-6
CYP1A2 *1F/*1KLA19107-4
CYP1A2 *1K/*1CLA19109-0

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.44
Last Updated
Version 2.68 (NAM)
Change Reason
Release 2.68: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; COMPONENT: Updated Component to align with the LOINC term naming model for concepts used to report allelic genotypes (e.g. CYP1A2*1C/*1F ), which was the original intent for this term.; Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; Previous Releases: Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen CYP1A2 alela:Genotyp:Časový bod:Krev/tkáň:Nominální:Molekulární genetika
el-GRGreek (Greece)Αλληλόμορφο γονιδίου CYP1A2:Geno:Pt:Αίμα/Ιστός:Nom:Μοριακή γενετική
Synonyms: Geno MOLPATH MOLPATH.PHARMG Nom Pt Αίμα Αίμα/Ιστός Αλληλόμορφο γονιδίου CYP1A2 Γονίδιο Γονίδιο CYP1A2 Ιστός Μοριακή γενετική
es-ESSpanish (Spain)Alelo del gen CYP1A2:Genotipo:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MXSpanish (Mexico)Alelo del gen CYP1A2:Genotipo:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FRFrench (France)CYP1A2 gène allèle:Génotype:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-ITItalian (Italy)CYP1A2, gene allele:Geno:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Farmacogenomica Gene CYP1A2 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)CYP1A2-allel:genotype:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: molgen
pl-PLPolish (Poland)CYP1A2 gen allel:genotyp:punkt w czasie:krew lub tkanka:skala nominalna:genetyka molekularna
Synonyms: Allel genu CYP1A2 diagnostyka molekularna Gen CYP1A2 wynik kategorialny
pt-BRPortuguese (Brazil)CYP1A2 gene análise de mutação:Ident:Pt:Sg/Tecido:Nom:Genética molecular
zh-CNChinese (China)CYP1A2 基因等位基因:基因型:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 细胞色素P450, 家族1, 亚家族A, 肽2;cytochrome P450, family 1, subfamily A, polypeptide 2;铁离子结合;氧结合;血红素结合;金属离子结合;非特异性单加氧酶 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72884-0