74037-3

Transmissible spongiform encephalopathy [Identifier] in Brain by Light microscopy

Active

Term Description

Specific histopathologic exam without immunostain to identify and classify TSE (Scrapie, CWE, and BSE). Findings on light microscopy (plaques, neuronal loss, etc.) indicate the disease process, which is used to classify the disease.

Part Description

LP173528-3 Transmissible spongiform encephalopathy
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

LOINC Names Get Info

Fully-Specified Name: Transmissible spongiform encephalopathy:Prid:Pt:Brain:Nom:Microscopy.light
Long Common Name: Transmissible spongiform encephalopathy [Identifier] in Brain by Light microscopy
Short Name: TSE Brain Micro
Display Name: Transmissible spongiform encephalopathy LM Nom (Brain)
Consumer Name Alpha Get Info: Transmissible spongiform encephalopathy, Brain

Part Model Get Info

Component
Transmissible spongiform encephalopathy
LP173528-3
- Analyte
  Transmissible spongiform encephalopathy
  LP173528-3
  - Component Numerator
    Transmissible spongiform encephalopathy
    LP173528-3
    - Component Numerator Core
      Transmissible spongiform encephalopathy
      LP173528-3
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Prid
LP6850-4
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Brain
LP7084-9
- System Core
  Brain
  LP7084-9
- Super System
  NULL
Scale
Nom
LP7750-5
Method
Microscopy.light
LP6398-4

Example Answer List: LL2535-4

Source: American Association of Veterinary Laboratory Diagnosticians

Answer	Code	Score	Answer ID
Bovine spongiform encephalopathy (BSE) - C type Classical BSE (C type)			LA20104-8
Atypical Bovine spongiform encephalopathy (BSE) - H or L type H or L type BSE			LA20105-5
Scrapie			LA20108-9
Atypical scrapie			LA20109-7
Nor98			LA20111-3
Chronic wasting disease (CWD)			LA20110-5
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.46
Last Updated: Version 2.46 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Encefalopatie transmisivní spongiformní:Přítomnost nebo identita:Časový bod:Mozek:Nominální:Mikroskopie světelná
de-DE	German (Germany)	Transmissible spongiforme Enzephalopathie:Nachweis oder Identität:Zeitpunkt:Gehirn:Nominal:Mikroskopie.Licht
el-GR	Greek (Greece)	Μεταδοτική σπογγώδης εγκεφαλοπάθεια:Prid:Pt:Εγκέφαλος:Nom:Μικροσκόπηση.φωτός Synonyms: MICRO Nom Prid Pt Εγκέφαλος Μεταδοτική σπογγώδης εγκεφαλοπάθεια Μικρoσκόπιση Μικροσκόπηση.φωτός
es-ES	Spanish (Spain)	Encefalopatía espongiforme transmisible:Presencia o identidad:Punto temporal:Cerebro:Nom:Microscopía de luz
es-MX	Spanish (Mexico)	Encefalopatía espongiforme transmisible:Presencia o identidad:Punto temporal:Cerebro:Nominal:Microscopía óptica
fr-CA	French (Canada)	Encéphalopathie spongiforme transmissible:Présence ou identité:Temps ponctuel:Cerveau:Nominal:Microscopie.fond clair
fr-FR	French (France)	Encéphalopathie spongiforme transmissible:Identification:Ponctuel:Cerveau:Résultat nominal:Microscopie optique
it-IT	Italian (Italy)	Encefalopatie spongiformi trasmissibili:Prid:Pt:Cervello:Nom:Microscopia.ottica Synonyms: Microbiologia Microscopia ottica Presenza o Identità Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	overdraagbare spongiforme encefalopathie:identificator:moment:hersenen:nominaal:microscopie.licht Synonyms: lichtmicroscopie
pt-BR	Portuguese (Brazil)	Encefalopatia espongiforme transmissível:Ident:Pt:Cérebro:Nom:Microscopia optica
ru-RU	Russian (Russian Federation)	Трансмиссивная губчатая энцефалопатия:ПрИд:ТчкВрм:Головной мозг:Ном:Микроскопия.световой Synonyms: Номинальный;Именной Присутствие или Идентификация Точка во времени;Момент
tr-TR	Turkish (Turkey)	Bulaşan spongiform ensefalopati:MevcKimlik:Zmlı:Beyin:Snf:Mikroskopi.ışık
zh-CN	Chinese (China)	传染性海绵状脑病:存在与否或特征标识:时间点:脑部:名义型:显微镜检查.光学 Synonyms: 光学显微镜方法;光学显微镜方法.光学;光学显微镜检;光学显微镜检.光学;光学显微镜检查;光镜检查;光镜检查.光学;光镜法;显微镜检查.普通光学;普通光学显微镜检查;镜检;镜检.光学分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答可传播性海绵状脑病;传染性海棉状脑病变;传染性海绵样脑病大脑;大脑的;头;头部;头颅内;头颅内的;脑的;脑;颅内;颅内的;颅骨内;颅骨内的存在;存在与否;特征标识;身份;身份标识微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间显微学;显微术;显微镜学;显微镜检术;显微镜检查;显微镜检查方法;显微镜检查法;显微镜检查类方法;显微镜检查类检验方法;显微镜法;镜检;镜检术;镜检法

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